PMID: 2483442Jan 1, 1989Paper

Clinical pharmacology of inodilators.

Journal of Cardiovascular Pharmacology
L Dei CasO Visioli

Abstract

Recent advances in our knowledge of heart failure have shown that both a central and a peripheral factor are involved in this syndrome. Therefore, the ideal drug should combine the properties of a positive inotropic agent with those of a peripheral vasodilator; many drugs recently introduced into clinical practice have been shown to present both of these features, and the term "inodilators" has been used to characterize them. Inodilators can be further classified on the basis of their mechanism of action, i.e., phosphodiesterase inhibitors, and sympathomimetic and dopaminergic drugs. Phosphodiesterase inhibitors include bipyridine, imidazolone, and benzimidazole derivatives, which present potent inotropic and vasodilatatory actions. Despite their favorable acute effects, long-term studies have often yielded controversial, and sometimes disappointing, results as their chronic administration seems often to be associated with untoward effects and, above all, a poor prognosis. Sympathomimetic agonists act by stimulation of beta-receptors, with a consequent increase of myocardial contractility and peripheral vasodilation. Differently from the parenteral drugs (e.g., dobutamine), the oral agents present many important shortcomings in...Continue Reading

Citations

Dec 2, 2014·Critical Care Clinics·Eliezer L BoseMichael R Pinsky
Mar 1, 1995·Clinical Cardiology·M Metra, L Dei Cas
Dec 1, 1994·Biopharmaceutics & Drug Disposition·H F StampfliC Y Quon
Jan 1, 1990·Journal of Autonomic Pharmacology·C CasagrandeA La Regina
Nov 19, 2002·São Paulo Medical Journal = Revista Paulista De Medicina·José Antônio Baddini MartinezJoão Terra Filho

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