PMID: 6160344Jan 1, 1981Paper

Clinical pharmacology of prazosin in hypertensive patients with chronic renal failure

Journal of Cardiovascular Pharmacology
M ChaignonJ Guedon

Abstract

The clinical pharmacology of prazosin was studied in 10 hypertensive patients with chronic renal failure (group I) and in 9 hypertensive patients with normal renal function (group II). Prazosin, 2 mg, was given orally and blood samples were drawn at intervals for spectrofluorimetric assay. Blood pressure and heart rate were obtained at the same time. In the renal failure group, prazosin induced a significant decrease in systolic and diastolic blood pressures (-19 and -23%, respectively) at 90 min after intake, and these alterations were more rapid and marked than in the normal renal function group. Peak plasma concentration (Cmax) was higher (33.5 +/- 3.7 vs. 20.04 +/- 1.7 micrograms/liter, p < 0.01) and occurred earlier (1.3 +/- 0.2 vs. 2.7 +/- 0.3 hr, p < 0.005) in group I than in group II. The area under the plasma concentration-time curve (AUC0 infinity) was increased in the renal failure group (206.1 +/- 31.1 vs. 112.4 +/- 9.4 micrograms/hr/liter, p < 0.01). Apparent plasma elimination half-life (t 1/2) was not significantly different in the two groups (3.6 +/- 0.4 vs. 2.9 +/- 0.3 hr. ns). The mean blood pressure change (delta MBP%) was significantly correlated with the plasma level of prazosin in the renal failure group (...Continue Reading

Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·H L ElliottJ L Reid
Jan 1, 1986·European Journal of Clinical Pharmacology·N Lameire, J Gordts
May 23, 1986·The American Journal of Medicine·P JungersP Chauveau
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·P Seideman

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