Clinical pharmacology of sulphonylurea hypoglycaemic agents: part 1

Drugs
J E Jackson, R Bressler

Abstract

The sulphonylureas are drugs of limited efficacy with fairly frequent, although usually reversible, adverse effects. Being highly protein bound, these drugs are subject to potential displacement interactions, which when combined with inhibition of their elimination, may result in profound hypoglycaemia. Due to hepatic metabolism and renal excretion of the parent drug and/or active metabolites, these agents are contraindicated in patients with liver or kidney disease. Oral hypoglycaemic agents are frequently used in elderly patients with limited vision and no dependable relatives, who cannot give themselves insulin. It is these patients--elderly, living alone in poor circumstances, often on several other medications, and possibly malnourished--who are at greatest risk for catastrophic hypoglycaemia with these drugs. Long acting agents like chlorpropamide and glibenclamide should be avoided in the elderly and in patients with irregular eating habits. Diet and exercise remain the primary modes of therapy of non-insulin-dependent diabetes mellitus. With careful patient selection and attention to drug and disease interactions, the sulphonylureas may be a useful adjunct to diet in treating a small proportion of insulin-resistant (so-...Continue Reading

Citations

Feb 1, 1990·Journal of Clinical Pharmacology·L A JaberE J Antal
Aug 1, 1987·Pflügers Archiv : European journal of physiology·B BellesG Trube
Jan 1, 1985·European Journal of Clinical Pharmacology·C R SirtoriE Bosisio
Jan 1, 1985·European Journal of Clinical Pharmacology·L GroopF Fyhrqvist
Jan 1, 1987·European Journal of Clinical Pharmacology·G F PeartG M Shenfield
Apr 12, 2008·Journal of Natural Medicines·René KamgangJeanne Ngogang Yonkeu
Oct 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·N A RoachR J Elin
Feb 14, 1995·European Journal of Pharmacology·E N KosmasS N Hussain
Feb 3, 1994·European Journal of Pharmacology·Z Abrahams, M C Sutter
Jan 1, 1995·Life Sciences·C M KuhnM N Feinglos
Feb 1, 1986·Journal of Ethnopharmacology·A S Undie, P I Akubue
Jun 18, 2002·Journal of Ethnopharmacology·John A O Ojewole
Jun 1, 1997·Journal of Clinical Epidemiology·T van StaaJ Monette
May 1, 1988·Baillière's Clinical Endocrinology and Metabolism·A Melander
May 14, 1999·British Journal of Pharmacology·T OhtaK Wakitani
Aug 8, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Linjun GuoMasaru Tanokura
Aug 23, 2006·Clinical and Experimental Pharmacology & Physiology·A A OdetolaA O Ayoola
Apr 8, 1998·The Journal of Pharmacy and Pharmacology·N NishimuraK Iwamoto
May 14, 1983·British Medical Journal·N PedenJ Feely
Jun 23, 2005·BMC Complementary and Alternative Medicine·Ramalingam Saravanan, Leelavinothan Pari
Feb 25, 2014·Current Diabetes Reports·Peter M Thulé, Guillermo Umpierrez
Dec 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M LudwigC Faiman
Jul 1, 1985·Mayo Clinic Proceedings·J E Gerich
Feb 18, 2016·Journal of Diabetes Research·Anoja Priyadarshani AttanayakeLakmini Kumari Boralugoda Mudduwa
Nov 30, 1983·The American Journal of Medicine·A Melander, E Wåhlin-Boll
Jan 17, 1983·The American Journal of Medicine·R A DeFronzoV Koivisto
Oct 1, 1984·British Journal of Clinical Pharmacology·A SamantaI Shakir
Oct 1, 1983·British Journal of Clinical Pharmacology·N G DeyA McBurney
May 1, 1987·Journal of the American Geriatrics Society·M J RosenthalD Osterweil
Oct 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·H Beck-NielsenO Pedersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.