PMID: 6987361Apr 1, 1980Paper

Clinical pharmacology of two chloramphenicol preparations in children: sodium succinate (iv) and palmitate (oral) esters

The Journal of Pediatrics
L K PickeringT G Cleary

Abstract

The clinical pharmacology of chloramphenicol was evaluated in 14 children with serious bacterial infections. The children received chloramphenicol sodium succinate intravenously for five to six days at which time orally administered chloramphenicol palmitate was substituted for an additional five to six days of therapy. The mean peak serum chloramphenicol concentration when given iv (28.2 +/- 5.1 micrograms/ml) occurred within one hour after the termination of the 60-minute iv infusion and when given orally (19.3 +/- 2.6 micrograms/ml) occurred two to three hours after ingestion. Differences in serum levels of chloramphenicol after iv compared to oral administration of the same dose could be demonstrated at various time points studied during the dose-response curves; however, the areas under the chloramphenicol curve were not significantly different after iv (140 +/- 116 micrograms/ml/hour) versus oral (95 +/- 26 micrograms/ml/hour) administration. In seven patients who had concomitant serum and CSF chloramphenicol levels determined, a CSF to serum ratio of 23 to 85% occurred. The CSF levels (5.5 to 13 micrograms/ml) were not directly proportional to serum levels. All patients recovered from their infection and no side effects ...Continue Reading

References

Feb 1, 1978·The Journal of Pediatrics·S B BlackH R Shinefield
May 1, 1978·The Journal of Antimicrobial Chemotherapy·R W Barling, J B Selkon
Mar 1, 1978·Antimicrobial Agents and Chemotherapy·L M Dunkle
Mar 1, 1979·The Journal of Pediatrics·R S DaumA L Smith
Dec 27, 1969·Lancet·L K Christensen, L Skovsted
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Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·M ErikssonT W Mariam
Mar 1, 1992·Indian Journal of Pediatrics·Z A BhuttaA Suria
May 22, 1981·Biochimica Et Biophysica Acta·W C ChangS Murota
Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·G D Overturf
Jul 1, 1984·The Journal of Pediatrics·S Shankaran, R E Kauffman
Oct 8, 2013·CNS Spectrums·Laure-Sophie Camilla d'AngeloSamuel R Chamberlain
Sep 1, 1981·Antimicrobial Agents and Chemotherapy·J L WeeksC J Baker
Apr 1, 1986·Antimicrobial Agents and Chemotherapy·A M Mackenzie, F T Chan
Nov 12, 1983·British Medical Journal·A MulhallR Hurley
Jan 24, 2004·Annals of Tropical Paediatrics·David G FullerNigel Curtis
Apr 1, 1984·Journal of Clinical Pharmacology·W G KramerL K Pickering
Jun 1, 1981·The Journal of Pediatrics·S A ChartrandD C Plunket
Nov 1, 1980·The Journal of Pediatrics·S J Matthews, S Shawver-Matthews
Dec 1, 1981·The Journal of Pediatrics·E I TuomanenA L Smith
Apr 1, 1982·Drug Intelligence & Clinical Pharmacy·D A Powell, M C Nahata

Related Concepts

Biopharmaceutics
Syntomycin
Escherichia Coli Infections
Haemophilus Infections
Haemophilus influenzae
Parenteral Infusion
Meningitis, Haemophilus Parainfluenzae
Typhoid Fever
Pyemia

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