Clinical Phenotypes and Long-term Prognosis in White Patients With Biopsy-Verified Hypertensive Nephrosclerosis

KI Reports
Marius A ØvrehusStein I Hallan

Abstract

Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it is still an insufficiently studied and controversial disease entity. More information on the phenotype and prognosis is needed to improve clinical diagnostics and treatment. We included all Norwegian patients with chronic kidney disease (CKD) referred for kidney biopsy between 1988 and 2012 whose clinical presentation was consistent with, but not primarily suspicious for, hypertensive nephrosclerosis (n = 4920); follow-up continued until 2013. A total of 918 patients (19%) had biopsy-verified hypertensive nephrosclerosis (i.e., arterionephrosclerosis). Their most common biopsy indications were proteinuria (57%), low estimated glomerular filtration rate (eGFR) (44%), hematuria (34%), or combinations of these indications. Multivariable logistic regression analysis revealed that arterionephrosclerosis was significantly associated with higher age, male sex, not having diabetes, higher blood pressure, lower proteinuria, and not having hematuria (P < 0.01 for all). Body mass index, cholesterol, high-density lipoprotein cholesterol, and eGFR were not significantly associated with arterionephrosclerosis (P > 0.05 for all). ...Continue Reading

Citations

Aug 14, 2020·The Korean Journal of Internal Medicine·Kipyo KimUNKNOWN Korean GlomeruloNEphritis sTudy (KoGNET) Group
Feb 20, 2021·Clinical and Experimental Nephrology·Yoshifumi UbaraUNKNOWN Committee of Practical Guide for Kidney Biopsy 2020
Jun 3, 2021·International Journal of Molecular Sciences·Domenico SantoroGiorgina Barbara Piccoli

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Biopsy
biopsies
electron

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