PMID: 16536012Mar 16, 2006Paper

Clinical pictures of bronchial asthma in children

Pneumologia : revista Societății Române de Pneumologie
Angela Butnariu, Diana Giurgiui

Abstract

In the tip-to-date medical literature a topic for discussion is the variety of asthma clinical phenotypes. The knowledge of the various clinical asthma phenotypes is very important as regards the appropriate treatment approach, and the prognostic assessment of the patients with asthma. This allows a better understanding of pathophysiologic mechanisms, and of the phenotype-genotype correlation. A diagrammatic classification of clinical asthma phenotypes includes following criteria: onset age, inflammatory profile, severity pattern. According to the onset age, asthma clinical phenotypes specific for children and clinical phenotypes more frequent in adulthood are known. The main childhood asthma phenotypes are: transient infant wheezing, non atopic wheezing of the toddler and early school years, persistent IgE-mediated wheezing/asthma, late-onset childhood asthma. Other asthma phenotypes like aspirin-induced asthma, asthma related to chronic, persistent respiratory infection, are rare in childhood. It is reported a prevalence of 2-5% for the aspirin-induced asthma among pediatric patients. According to the airway inflammation pattern there are two phenotypes to distinguish: eosinophilic and non-eosinophilic asthma. The majority of...Continue Reading

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