Clinical pilot study of transcranial direct current stimulation combined with Cognitive Emotional Training for medication resistant depression

Journal of Affective Disorders
Donel MartinC K Loo

Abstract

While the clinical results from transcranial direct current stimulation (tDCS) for the treatment of depression have been promising, antidepressant effects in patients with medication resistance have been suboptimal. There is therefore a need to further optimise tDCS for medication resistant patients. In this clinical pilot study we examined the feasibility, safety, and clinical efficacy of combining tDCS with a psychological intervention which targets dysfunctional circuitry related to emotion regulation in depression, Cognitive Emotional Training (CET). tDCS was administered during CET three times a week for a total of 18 sessions over 6 weeks. Mood, cognition and emotion processing outcomes were examined at baseline and after 3 and 6 weeks of treatment. Twenty patients with medication resistant depression participated, of whom 17 were study completers. tDCS combined with CET was found to be feasible, safe, and associated with significant antidepressant efficacy at 6 weeks, with 41% of study completers showing treatment response (≥ 50% improvement in depression score). There were no significant cognitive enhancing effects with the exception of improved emotion recognition. Responders demonstrated superior recognition for the e...Continue Reading

Citations

Aug 29, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Emma S WelchLinda L Carpenter
Jul 10, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Valentina CiulloFederica Piras
Mar 19, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Lucas BorrioneAndre R Brunoni
Dec 15, 2020·Current Treatment Options in Psychiatry·Kathryn R CullenBonnie Klimes-Dougan
Feb 22, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Morená M ZuglianiRafael C Freire

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