PMID: 7740422May 1, 1995Paper

Clinical pilot study on high-dose intraarterial chemotherapy with direct hemoperfusion under hepatic venous isolation in patients with advanced hepatocellular carcinoma

Surgery
Y KuH Obara

Abstract

We recently developed a novel system of direct hemoperfusion under hepatic venous isolation in an attempt to achieve high-dose intraarterial chemotherapy for patients with malignant liver tumors. We report here the results of treatment of these patients with advanced hepatocellular carcinoma. Adriamycin (100 to 150 mg/m2) was administered into the hepatic artery of 15 patients, under conditions of extracorporeal drug elimination by direct hemoperfusion under hepatic venous isolation. Hepatic venous isolation was accomplished mainly by the double-balloon technique with an occlusion catheter and a balloon catheter. The isolated hepatic venous blood was filtered by direct hemoperfusion and pumped to the left axillary vein. During 5 minutes of adriamycin infusion, the mean drug extraction ratios of the direct hemoperfusion filters were 91% +/- 9% (mean +/- SD). The amount of drug removed by the system was 26.4% +/- 16.0% of the amount of drug administered. Two patients died, one of necrotizing pancreatitis and the other of hepatic arterial thrombosis. Both deaths were related directly to the hepatic arterial catheter. Other side effects included hemolysis related to the system of hemoperfusion (87%), chemical hepatitis (80%), leuko...Continue Reading

Citations

Jan 1, 2016·Cardiovascular and Interventional Radiology·Mark C BurgmansArian R van Erkel
Aug 30, 2008·Surgical Oncology Clinics of North America·Takeshi MaruoYonson Ku
Apr 24, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·R López-BenítezP J Hallscheidt
Mar 16, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A AverbachP H Sugarbaker
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P CzaudernaUNKNOWN Liver Tumors Study Group of the International Society of Pediatric Oncology

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