Clinical potential of DAS181 for treatment of parainfluenza-3 infections in transplant recipients

Transplant Infectious Disease : an Official Journal of the Transplantation Society
B B Guzmán-SuarezS Koo

Abstract

Parainfluenza virus (PIV) infections can cause serious respiratory infections and death in immunocompromised patients. No antiviral agents have proven efficacy against PIV, and therapy generally consists of supportive care. DAS181, a novel sialidase fusion protein that temporarily disables airway epithelial PIV receptors by enzymatic removal of sialic acid moieties, has been shown to inhibit infection with PIV strains in vitro and in an animal model. We describe here the clinical course of 2 immunocompromised patients with PIV-3 infection, one with a history of lung transplantation and the other neutropenic after autologous hematopoietic stem cell transplantation for multiple myeloma. Both patients had substantial clinical improvement in respiratory and systemic symptoms after a 5-day DAS181 treatment course, although the clinical improvement in the autologous stem cell transplantation patient also paralleled neutrophil engraftment.

References

Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·F W Denny
Nov 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V A LewisE Whimbey
Jun 23, 2001·The New England Journal of Medicine·C B Hall
Nov 10, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R A VilchezS Kusne
Feb 27, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Regis A VilchezShimon Kusne
Nov 17, 2007·The Journal of Infectious Diseases·Jessica A BelserJacqueline M Katz
Sep 13, 2008·British Journal of Haematology·Michael Boeckh
May 12, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A WeinbergM R Zamora
Jul 10, 2010·Drugs·David A BoltzElena A Govorkova
May 17, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeffrey L LarsonFang Fang
Sep 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yi-Bin ChenFrancisco M Marty

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Citations

Oct 23, 2013·Current Infectious Disease Reports·Dana HawkinsonLara Danziger-Isakov
Oct 10, 2012·The Journal of Infectious Diseases·Michael G Ison
Jun 29, 2013·Current Opinion in Infectious Diseases·Sarah Shalhoub, Shahid Husain
Oct 30, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roy F ChemalyMichael J Boeckh
Dec 3, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Frederick R AppelbaumMary M Horowitz
Nov 14, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cynthia E FisherAjit P Limaye
Feb 26, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mirella SalvatoreRosemary Soave
Sep 24, 2015·Antiviral Research·Jonathan M ZenilmanJ McLeod Griffiss
Nov 15, 2013·Influenza and Other Respiratory Viruses·Michael G Ison
Nov 15, 2013·Influenza and Other Respiratory Viruses·Frederick G Hayden
Jan 4, 2013·Influenza and Other Respiratory Viruses·Frederick G Hayden
Jan 3, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D R DrozdR M Rakita
Jan 5, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S ChalkiasC S Tan
Jul 18, 2015·Journal of the Pediatric Infectious Diseases Society·Alpana WaghmareJanet A Englund
Apr 23, 2013·Antiviral Research·John M NichollsStuart M Haslam
Nov 27, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I HelanteräM Lempinen
Jan 10, 2017·Expert Review of Anti-infective Therapy·Lokesh ShahaniRoy F Chemaly
Apr 21, 2017·Expert Opinion on Pharmacotherapy·Shellee A GrimNina M Clark
Mar 15, 2014·Current Opinion in Pulmonary Medicine·Alyssa R LetourneauLindsey R Baden
May 5, 2017·The Journal of Infectious Diseases·Alpana WaghmareMichael Boeckh
Apr 3, 2019·Current Opinion in Organ Transplantation·Jens Gottlieb
Sep 13, 2019·Clinical Microbiology Reviews·Michael G Ison, Hans H Hirsch
Jun 8, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elliott Russell, Michael G Ison
Jan 9, 2019·Frontiers in Microbiology·Diego R HijanoRandall T Hayden
Nov 18, 2016·Critical Care : the Official Journal of the Critical Care Forum·Guillaume VoiriotJean-François Timsit
Jul 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elliott RussellMichael G Ison
May 16, 2019·Current Opinion in Organ Transplantation·Jens Gottlieb
Feb 12, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roy F ChemalyMichael Boeckh
Aug 28, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sachiko SeoMichael Boeckh

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