Abstract
Meningiomas are among the most common intracranial pathological conditions, accounting for 36% of intracranial lesions treated by neurosurgeons. Although the majority of these lesions are benign, the classical categorization of tumors by histological type or World Health Organization (WHO) grade has not fully captured the potential for meningioma progression and recurrence. Many targeted treatments have failed to generate a long-lasting effect on these tumors. Recently, several seminal studies evaluating the genomics of intracranial meningiomas have rapidly changed the understanding of the disease. The importance of NF2 (neurofibromin 2), TRAF7 (tumor necrosis factor [TNF] receptor-associated factor 7), KLF4 (Kruppel-like factor 4), AKT1, SMO (smoothened), PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), and POLR2 (RNA polymerase II subunit A) demonstrates that there are at least 6 distinct mutational classes of meningiomas. In addition, 6 methylation classes of meningioma have been appreciated, enabling improved prediction of prognosis compared with traditional WHO grades. Genomic studies have shed light on the nature of recurrent meningioma, distinct intracranial locations and mutational patter...Continue Reading
References
Oct 22, 2003·Journal of Neurosurgery·Raj K ShrivastavaKalmon D Post
Dec 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rong RongKeqiang Ye
Dec 13, 2005·Nature Cell Biology·Fisun HamaratogluGeorg Halder
Jan 10, 2006·Neurosurgical Focus·Brian T Ragel, Randy L Jensen
Jan 20, 2007·Cancer Research·Helen MorrisonPeter Herrlich
May 20, 2009·Molecular and Cellular Biology·Marianne F JamesVijaya Ramesh
Sep 15, 2010·Journal of Neuro-oncology·Brian T Ragel, Randy L Jensen
Jan 15, 2011·Acta neurochirurgica·Mads AarhusPer Morten Knappskog
May 3, 2011·Neurosurgical Focus·Martin H PhamWilliam J Mack
Mar 20, 2012·Molecular Cancer Research : MCR·Marianne F JamesVijaya Ramesh
Apr 5, 2012·Neurosurgery·Randy Jensen, Janet Lee
Jan 22, 2013·Nature Genetics·Priscilla K BrastianosRameen Beroukhim
Jan 26, 2013·Science·Victoria E ClarkMurat Günel
Oct 3, 2015·World Neurosurgery·Michael KarsyRandy L Jensen
Oct 30, 2015·Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
Jan 16, 2016·Journal of Neurosurgery·Wenya Linda BiIan F Dunn
Jan 31, 2016·Neuro-oncology·Malak AbedalthagafiSandro Santagata
Mar 26, 2016·Neurosurgery Clinics of North America·Mark S ShiroishiChia-Shang J Liu
Mar 26, 2016·Neurosurgery Clinics of North America·Michael KarsyRandy L Jensen
May 10, 2016·Acta Neuropathologica·David N LouisDavid W Ellison
Jun 23, 2016·Neurosurgery·Antonio Di IevaMichael D Cusimano
Aug 23, 2016·Nature Genetics·Victoria E ClarkMurat Günel
Sep 7, 2016·The Lancet Oncology·Roland GoldbrunnerMichael Weller
Mar 21, 2017·The Lancet Oncology·Felix SahmAndreas von Deimling
Apr 1, 2017·Journal of Neurosurgery·Michael KarsyRandy L Jensen
Jul 18, 2017·NPJ Genomic Medicine·Wenya Linda BiRameen Beroukhim
Sep 20, 2017·Cell Communication and Signaling : CCS·Yu MeiIan F Dunn
Nov 18, 2017·PloS One·Thibaud P CorollerHugo J W L Aerts
Jan 6, 2018·Nature Reviews. Neurology·Matthias PreusserChristian Mawrin
Citations
Dec 4, 2019·Neurosurgery·Susanne Peetz-DienhartBenjamin Brokinkel
May 2, 2019·Acta Neuropathologica Communications·Angela N ViaeneNadia Dahmane
Mar 4, 2020·Neurosurgery·Hanus SlavikJosef Srovnal
Sep 26, 2020·Frontiers in Oncology·Lianhua ZhaoZaiyu Guo
Sep 29, 2020·Frontiers in Oncology·Jiachen LiuGaiqing Wang
Sep 29, 2020·Frontiers in Oncology·Alexander F HaddadManish K Aghi
Oct 9, 2018·Frontiers in Immunology·Sining ZhuPing Xie
Jan 23, 2020·Cancers·Maria-Magdalena GeorgescuAdriana Olar
Nov 3, 2020·Current Neurology and Neuroscience Reports·Pedro David Delgado-LópezJavier Martín-Alonso
Dec 22, 2020·Oncotarget·Ahmad A NazemManuel J Ferreira
Oct 25, 2020·Cancers·Katharina HessMartin Albrecht
Jan 16, 2021·International Journal of Molecular Sciences·Suha BachirSoma Sengupta
Apr 4, 2021·Biomedicines·Christian OgasawaraD Cory Adamson
Jun 3, 2021·Cancers·Paul E ConstanthinTorstein R Meling
Aug 6, 2021·Journal of Neuro-oncology·Lan JinJennifer Moliterno