Clinical potential of the ERG oncoprotein in prostate cancer.

Nature Reviews. Urology
Philip RosenAlbert Dobi

Abstract

Oncogenic activation of ERG resulting from gene fusion is present in over half of all patients with prostate cancer in Western countries. Although the underlying genetic mechanisms have been extensively studied, evaluation of the ERG oncoprotein--the translational product of ERG gene fusions--has just begun. The robust correlation between ERG oncoprotein detection and gene fusion status enables rapid characterization of this protein in large patient cohorts. Recent studies have focused on characterizing the ERG oncoprotein and determining its potential role in the diagnosis and biological stratification of prostate cancer.

References

Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E S ReddyT S Papas
Jan 14, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M BaltzingerP Remy
Mar 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Claudia D BaldusAlbert de la Chapelle
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Nov 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido MarcucciClara D Bloomfield
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seung-Jae MyungSanford D Markowitz
Aug 4, 2006·Cancer Research·Ido WolfH Phillip Koeffler
Oct 13, 2006·Neoplasia : an International Journal for Oncology Research·Nuno CerveiraManuel R Teixeira
Dec 19, 2006·Nature Genetics·Scott A TomlinsArul M Chinnaiyan
Jan 30, 2007·Journal of Clinical Pathology·Ashish B RajputDavid G Huntsman
May 29, 2007·The American Journal of Surgical Pathology·Sven PernerMark A Rubin
Dec 22, 2007·Expert Review of Anticancer Therapy·David P Turner, Dennis K Watson
Feb 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Olga KlezovitchValeri Vasioukhin
Feb 20, 2008·Neoplasia : an International Journal for Oncology Research·Scott A TomlinsArul M Chinnaiyan
May 27, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Maisa YoshimotoJeremy A Squire
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Juan-Miguel MosqueraMark A Rubin
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Outi R SaramäkiTapio Visakorpi
Jun 20, 2008·Nature Reviews. Cancer·Chandan Kumar-SinhaArul M Chinnaiyan
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying HuShiv Srivastava
Sep 11, 2008·British Journal of Cancer·S A NarodR Nam
Nov 26, 2008·Mechanisms of Development·Felix EllettGraham J Lieschke
Feb 5, 2009·Cancer Research·Anuradha GopalanWilliam L Gerald
Apr 28, 2009·Nature Genetics·Jennifer C KingCharles L Sawyers
May 2, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bo HanRajal B Shah
May 5, 2009·European Urology·Scott A TomlinsJack A Schalken
Jul 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yang ZongOwen N Witte
Aug 4, 2009·Neoplasia : an International Journal for Oncology Research·Dorothee PfluegerMark A Rubin
Aug 7, 2009·Nature Reviews. Urology·Jeremy P Clark, Colin S Cooper
Jan 28, 2010·British Journal of Cancer·A H M ReidUNKNOWN Transatlantic Prostate Group
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Veit J SchebleSven Perner

❮ Previous
Next ❯

Citations

May 21, 2013·International Urology and Nephrology·A Marcell SzászPéter Nyirády
Apr 9, 2013·Asian Journal of Andrology·Michael Dean, Hong Lou
Feb 13, 2013·Current Opinion in Oncology·Damali N MartinStefan Ambs
Jan 29, 2014·Prostate Cancer and Prostatic Diseases·J R GsponerC Ruiz
Oct 23, 2012·American Journal of Clinical Pathology·Allison YoungScott A Tomlins
May 22, 2013·American Journal of Clinical Pathology·Scott A TomlinsLakshmi P Kunju
Jun 16, 2015·Lancet·Gerhardt AttardJohann S de Bono
Sep 27, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Anna FlammigerMartin Trepel
Jun 11, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Deshui JiaXianghuo He
Mar 27, 2015·The Prostate·Kristen P NickensGyorgy Petrovics
May 21, 2016·Frontiers in Oncology·Hsin-Yi Chen, Ruey-Hwa Chen
Dec 4, 2014·Molecular and Clinical Oncology·Gregory M KellySok Ching Cheong
Sep 6, 2017·Nature Reviews. Urology·Jason SedarskyAlbert Dobi
Oct 4, 2014·Molecular and Clinical Oncology·James FarrellGyorgy Petrovics
Apr 30, 2017·Nature Reviews. Cancer·Gina M SizemoreMichael C Ostrowski
Aug 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alan Dal PraRobert G Bristow
Sep 20, 2015·Genes & Development·Kasper Jermiin KnudsenBo Torben Porse
Oct 14, 2021·Cancer Research·James R HawleyMathieu Lupien

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.