Clinical Practice. Postmenopausal Osteoporosis

The New England Journal of Medicine
Dennis M Black, Clifford J Rosen

Abstract

Key Clinical Points Postmenopausal Osteoporosis Fractures and osteoporosis are common, particularly among older women, and hip fractures can be devastating. Treatment is generally recommended in postmenopausal women who have a bone mineral density T score of -2.5 or less, a history of spine or hip fracture, or a Fracture Risk Assessment Tool (FRAX) score indicating increased fracture risk. Bisphosphonates (generic) and denosumab reduce the risk of hip, nonvertebral, and vertebral fractures; bisphosphonates are commonly used as first-line treatment in women who do not have contraindications. Teriparatide reduces the risk of nonvertebral and vertebral fractures. Osteonecrosis of the jaw and atypical femur fractures have been reported with treatment but are rare. The benefit-to-risk ratio for osteoporosis treatment is strongly positive for most women with osteoporosis. Because benefits are retained after discontinuation of alendronate or zoledronic acid, drug holidays after 5 years of alendronate therapy or 3 years of zoledronic acid therapy may be considered for patients at lower risk for fracture.

References

Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Jane A CauleyUNKNOWN Women's Health Initiative Investigators
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles H ChesnutUNKNOWN Oral Ibandronate Osteoporosis Vertebral Fracture Trial in North America and Europe (BONE)
Aug 12, 2005·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Feb 17, 2006·The New England Journal of Medicine·Rebecca D JacksonUNKNOWN Women's Health Initiative Investigators
Apr 12, 2006·Menopause : the Journal of the North American Menopause Society·Susan RichmanFrederick Naftolin
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rebecca D JacksonUNKNOWN Women's Health Initiative Investigators
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Dennis M BlackUNKNOWN FLEX Research Group
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
Sep 20, 2007·The New England Journal of Medicine·Kenneth W LylesUNKNOWN HORIZON Recurrent Fracture Trial
Mar 12, 2009·Journal of the National Cancer Institute·Steven R CummingsKarla Kerlikowske
Aug 13, 2009·The New England Journal of Medicine·Steven R CummingsUNKNOWN FREEDOM Trial
Mar 26, 2010·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial Steering Committee
Jun 18, 2010·The Journal of Clinical Endocrinology and Metabolism·I R ReidD M Black
Oct 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alexandra PapaioannouUNKNOWN Scientific Advisory Council of Osteoporosis Canada
Feb 19, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J D WarkT J de Villiers
Nov 2, 2011·The Journal of the American Dental Association·John W HellsteinUNKNOWN American Dental Association Council on Scientific Affairs Expert Panel on Antiresorptive Agents
Dec 14, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dennis M BlackRichard Eastell
Jan 26, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Adrianne C FeldsteinEric Orwoll
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Mohammad Hassan MuradVictor M Montori
Apr 24, 2012·The Journal of Clinical Endocrinology and Metabolism·Sundeep KhoslaJohn T Potts
May 11, 2012·The New England Journal of Medicine·Dennis M BlackClifford J Rosen
Feb 15, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lydia GedmintasSeoyoung C Kim
May 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth ShaneMichael P Whyte
Aug 21, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shreyasee AminL Joseph Melton
Oct 18, 2013·The New England Journal of Medicine·Douglas C Bauer
May 7, 2014·JAMA Internal Medicine·Douglas C BauerDennis M Black
Sep 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay
Sep 4, 2014·The New England Journal of Medicine·Jörg SchilcherKarl Michaëlsson
Sep 10, 2014·Annals of Internal Medicine·Carolyn J CrandallPaul G Shekelle
Sep 13, 2014·The Journal of Clinical Endocrinology and Metabolism·Felicia CosmanDennis M Black
Nov 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aliya A KhanUNKNOWN International Task Force on Osteonecrosis of the Jaw
Nov 25, 2014·Annals of Internal Medicine·Erin S LeBlancRoger Chou
Feb 11, 2015·Current Medical Research and Opinion·Ankita ModiShuvayu Sen
Mar 24, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Christopher J YatesJohn D Wark
Jun 18, 2015·Journal of Injury & Violence Research·Hosein KarimAlireza Ahmadi

❮ Previous
Next ❯

Citations

May 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Piergiorgio Messa
May 12, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T SugiyamaH Oda
Apr 8, 2016·Expert Opinion on Pharmacotherapy·Luigi GennariDaniela Merlotti
May 26, 2016·The New England Journal of Medicine·Dennis M Black, Clifford J Rosen
Jun 30, 2016·The New England Journal of Medicine·Pelin O Simsek KiperRoland Baron
Jun 21, 2016·Expert Review of Clinical Pharmacology·Letizia Vannucci, Maria Luisa Brandi
Aug 18, 2016·The New England Journal of Medicine·Catherine M ViscoliLawrence H Young
Sep 30, 2016·Frontiers in Physiology·Julie M HughesBarbara J Morgan
Nov 1, 2016·The New England Journal of Medicine·Clifford J Rosen, Julie R Ingelfinger
Sep 28, 2016·Expert Opinion on Pharmacotherapy·Letizia Vannucci, Maria Luisa Brandi
Nov 9, 2016·Sports Health·Marci A Goolsby, Nicole Boniquit
Apr 20, 2017·Journal of the American Geriatrics Society·Denise M BoudreauDelia Scholes
Mar 23, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiujun WangYina Zhang
May 4, 2017·The Journal of Bone and Joint Surgery. American Volume·Young-Chang ParkKyu-Hyun Yang
Feb 25, 2017·Journal of Cellular Physiology·Wanting LinYoichi Ezura
Jun 24, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep Khosla, Elizabeth Shane
Apr 11, 2017·Current Opinion in Rheumatology·Mélany Hars, Andrea Trombetti
Feb 28, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Francesca FontanaRoberto Civitelli
Jun 6, 2017·Bone Reports·Meagan A CaubleMark M Banaszak Holl
Apr 18, 2017·Current Treatment Options in Infectious Diseases·Caitlin A MoranIghovwerha Ofotokun
Jan 31, 2017·Endocrinology and Metabolism Clinics of North America·Yang ShenDorothy S Martinez
Nov 26, 2016·Clinics in Geriatric Medicine·Paloma Alejandro, Florina Constantinescu
Jan 19, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaElizabeth Shane
Jan 31, 2017·Endocrinology and Metabolism Clinics of North America·G Isanne Schacter, William D Leslie
Dec 14, 2016·Auris, Nasus, Larynx·Hiroshi SakaidaKazuhiko Takeuchi
Mar 31, 2017·JBJS Reviews·Pol Maria RommensAlexander Hofmann
Nov 24, 2016·Mayo Clinic Proceedings·James S GoodwinJacques Baillargeon
Jan 14, 2017·Metabolism: Clinical and Experimental·Annegreet G Veldhuis-Vlug, Clifford J Rosen
Apr 28, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Stewart G Albert, Supraja Reddy
Jul 15, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agnès FournierNathalie Chabbert-Buffet
Apr 15, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H SatoI Narita
Feb 16, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S RouxG Boire
Feb 28, 2018·Journal of Clinical Pharmacology·Kumpal MadrasiLi Li
May 3, 2018·Physiological Reviews·Florent Elefteriou
Aug 31, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C RouxT Thomas
Sep 7, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M J RothmannK H Rubin
Oct 5, 2017·Therapeutic Advances in Musculoskeletal Disease·Michael R McClung
Jul 2, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tishya Al WrenVicente Gilsanz
Dec 5, 2017·Therapeutic Advances in Musculoskeletal Disease·Willem F Lems, Hennie G Raterman
Jun 6, 2018·Expert Opinion on Drug Discovery·D MerlottiL Gennari
May 19, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M HoffB Schei
May 19, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y SuT C Y Kwok

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revue médicale suisse
Brigitte Uebelhart, René Rizzoli
Climacteric : the Journal of the International Menopause Society
P Anagnostis, J C Stevenson
Revue médicale suisse
Brigitte Uebelhart, René Rizzoli
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Vittorio FuscoOscar Bertetto
© 2022 Meta ULC. All rights reserved