Clinical predictors of antibiotic prescribing for acutely ill children in primary care: an observational study

The British Journal of General Practice : the Journal of the Royal College of General Practitioners
Kathryn O'BrienAdrian Edwards

Abstract

Antibiotic overuse and inappropriate prescribing drive antibiotic resistance. Children account for a high proportion of antibiotics prescribed in primary care. To determine the predictors of antibiotic prescription in young children presenting to UK general practices with acute illness. Prospective observational study in general practices in Wales. A total of 999 children were recruited from 13 practices between March 2008 and July 2010. Multilevel, multivariable logistic regression analysis was performed to determine predictors of antibiotic prescribing. Oral antibiotics were prescribed to 261 children (26.1%). Respiratory infections were responsible for 77.4% of antibiotic prescriptions. The multivariable model included 719 children. Children were more likely to be prescribed antibiotics if they were older (odds ratio [OR] 1.3; 95% confidence intervals [CI] = 1.1 to 1.7); presented with poor sleep (OR 2.7; 95% CI = 1.5 to 5.0); had abnormal ear (OR 6.5; 95% CI = 2.5 to 17.2), throat (OR 2.2; 95% CI = 1.1 to 4.5) or chest examination (OR 13.6; 95% CI = 5.8 to 32.2); were diagnosed with lower respiratory tract infection (OR 9.5; 95% CI = 3.7 to 25.5), tonsillitis/sore throat (OR 119.3; 95% CI = 28.2 to 504.6), ear infection (OR...Continue Reading

References

Aug 4, 2001·Archives of Pediatrics & Adolescent Medicine·R Mangione-SmithR L Kravitz
Oct 6, 2001·Current Opinion in Microbiology·J Trias
Oct 29, 2002·Patient Education and Counseling·Reginald DeschepperFlora M Haaijer-Ruskamp
Sep 14, 2007·The Journal of Antimicrobial Chemotherapy·Irene PetersenUNKNOWN SACAR Surveillance Subgroup
Oct 10, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Genevieve CadieuxMichael Libman
Oct 27, 2007·The Lancet Infectious Diseases·Jarold L CosbyChristopher C Butler
Jun 18, 2009·Archives of Disease in Childhood·A Clavenna, M Bonati
Dec 22, 2010·The Journal of Antimicrobial Chemotherapy·Verena Schneider-LindnerSamy Suissa
Mar 8, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Tanya Ali Haj-HassanDavid C Mant
Apr 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew T Pavia
Nov 17, 2011·The Journal of Antimicrobial Chemotherapy·Joanna C CrockerChristopher C Butler
Nov 7, 2012·International Journal of Antimicrobial Agents·António Teixeira RodriguesMaria Teresa Herdeiro
Nov 9, 2012·Journal of the American Board of Family Medicine : JABFM·Gijs ElshoutMarjolein Y Berger
Dec 27, 2012·Archives of Disease in Childhood·Eefje G P M de BontJochen W L Cals
Apr 2, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Mary A DuffyBruce Guthrie
Apr 9, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Kathryn O'BrienChristopher C Butler
Jul 10, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Cliodna A M McNultyChris C Butler
Jul 10, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Talley A VodickaUNKNOWN TARGET Programme team
Nov 2, 2013·The Journal of Antimicrobial Chemotherapy·Jordan R CovveyAlexander B Mullen
Feb 11, 2014·The Journal of Antimicrobial Chemotherapy·Joep van den Broek d'ObrenanAlike W van der Velden
Apr 24, 2014·Italian Journal of Pediatrics·Antonietta GiannattasioAlfredo Guarino
Jan 1, 2013·ISRN Family Medicine·Christina T RyborgJanus Laust Thomsen
Nov 20, 2015·Journal of the Pediatric Infectious Diseases Society·Jeffrey S GerberTheoklis E Zaoutis

❮ Previous
Next ❯

Citations

May 27, 2016·Pediatric Pulmonology·Mohinder SarnaStephen B Lambert
Mar 24, 2018·Current Opinion in Infectious Diseases·Sanjay V Patel, Stefania Vergnano
Jan 18, 2018·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Megan Rose WilliamsAlastair D Hay
May 18, 2020·The Journal of Antimicrobial Chemotherapy·S V PatelO van Hecke
Jun 26, 2018·The Journal of Antimicrobial Chemotherapy·Benedict HayhoeSonia Saxena
Jan 5, 2020·European Journal of Pediatrics·Daniel Wai Je ThamBalamurugan Tangiisuran
Apr 26, 2020·BMC Pediatrics·Gaston ArnoldaUNKNOWN CareTrack Kids investigative team
Jul 6, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mutsumi J KiokaJeffrey H Jennings

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.