Clinical Predictors of Coronary Artery Plaque Progression by Quantitative Serial Assessment Using 320-Row Computed Tomography Coronary Angiography in Asymptomatic Patients with Type 2 Diabetes Mellitus.

Journal of cardiology
Tetsu TanakaKengo Tanabe

Abstract

Natural history of coronary plaque progression (PP) in patients with diabetes mellitus (DM) remains unclear. This study aimed to investigate the clinical predictors of coronary PP in patients with DM. In this prospective observational study, we analyzed 70 asymptomatic patients (age, 64.4 years; male, 67%) with type 2 DM without prior history of coronary artery disease who underwent serial 320-row computed tomography coronary angiography with an interscan interval of more than 24 months (median 37.7 months). Study endpoint was PP, which was defined if coronary plaque volumes (PVs) at follow-up minus PVs at baseline was >0. We evaluated plaque composition using the Hounsfield Unit thresholds and insulin resistance estimated by the homeostasis model assessment of insulin resistance (HOMA-IR). Thirty-nine patients who showed PP had a higher increase in hemoglobin A1c (⊿HbA1c) from baseline to follow-up than those without PP (0.3% ± 0.8% vs -0.4% ± 1.1%; p = 0.01), although there was no statistical difference in HbA1c at baseline (7.1 ± 0.5% vs. 7.3 ± 1.4%; p = 0.24). In multivariable analysis, ⊿HbA1c [odds ratio (OR): 3.05; 95% confidence interval (CI): 1.39-6.67; p = 0.001] was an independent predictor for PP. Increase in low-den...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien
Jul 28, 2004·Diabetes Care·Frans J Th WackersUNKNOWN Detection of Ischemia in Asymptomatic Diabetics Investigators
Apr 2, 2008·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN PERISCOPE Investigators
Jun 18, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Jan 21, 2011·The New England Journal of Medicine·Gregg W StoneUNKNOWN PROSPECT Investigators
Nov 30, 2018·Journal of cardiology·Hirofumi SoejimaUNKNOWN JPAD Trial Investigators
Jul 29, 2019·Journal of Cardiovascular Computed Tomography·Sang-Eun LeeHyuk-Jae Chang

❮ Previous
Next ❯

Citations

Jul 31, 2021·Journal of Cardiovascular Computed Tomography·Michelle C WilliamsHarvey Hecht

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.