Clinical predictors of culprit plaque rupture assessed on intravascular ultrasound in acute coronary syndrome

Circulation Journal : Official Journal of the Japanese Circulation Society
Masaya KatoAkifumi Higashi

Abstract

Acute coronary syndrome (ACS) commonly results from vulnerable plaque rupture, and occasionally results from thrombus formation in lesions without plaque rupture. The aim of the present study was to clarify the clinical features of different etiology of ACS and clinical predictors of culprit plaque rupture assessed on intravascular ultrasound (IVUS). One hundred and ten ACS patients with emergent coronary angiography were classified into 2 groups based on the presence or absence of culprit plaque rupture assessed on IVUS. Clinical characteristics were compared between the 2 groups. Culprit coronary plaque rupture was observed in 60 patients (55%). Patients with plaque rupture were younger and were more likely to be male (P<0.03 and P<0.02, respectively). In the rupture group, the prevalence of metabolic syndrome was higher (P<0.002), and among the components of metabolic syndrome, waist circumference was greater and serum high-density lipoprotein cholesterol level was lower (P<0.0001 and P=0.0004, respectively). IVUS-assessed lesion remodeling index was greater in the rupture group (P<0.0001). On multivariate analysis metabolic syndrome was an independent predictor of culprit plaque rupture (odds ratio =5.26, 95% confidence int...Continue Reading

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Citations

Oct 3, 2012·The Journal of Rheumatology·Adnan N KianiMichelle Petri
Oct 25, 2012·The American Journal of Cardiology·Saurabh SanonRobert Chilton
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Sep 6, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichi OzakiTakashi Akasaka
Dec 11, 2019·Journal of Thrombosis and Haemostasis : JTH·Michelle M Harbin, Pamela L Lutsey
Nov 2, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Francesco GiallauriaCarmine Morisco

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