PMID: 2107249Feb 1, 1990Paper

Clinical predictors of infection of central venous catheters used for total parenteral nutrition

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
C W ArmstrongS Hunsberger

Abstract

To identify predictors of infection in catheters used for total parenteral nutrition (TPN), clinical and microbiological data were prospectively collected on 169 catheter systems (88 patients). Based on semiquantitative catheter cultures, infection was associated with a positive insertion site skin culture taken close to the time of catheter removal (relative risk [RR] = 4.50), especially one yielding greater than or equal to 50 colonies of an organism other than coagulase-negative staphylococci. Infection was also associated with erythema at the insertion site greater than 4 mm in diameter (RR = 2.93). In a subset of 67 catheters for which blood cultures were obtained, infection was also associated with a positive peripheral venous blood culture (RR = 5.90) and a positive central venous blood culture obtained through the catheter (RR = 5.44). Based on a logistic regression model, periodic cultures of the insertion site should be useful in evaluating subsequent fever in stable patients with indwelling central venous catheters. Another source of fever is likely if inflammation is absent and there is either no colonization or there is colonization by less than 50 colonies of coagulase-negative staphylococci at the insertion site....Continue Reading

Citations

Mar 1, 1996·Nutrition·K A Adal, B M Farr
Jun 29, 2000·Journal of the American College of Surgeons·S J PelletierR G Sawyer
Nov 16, 2004·Critical Care Medicine·Jonathan CohenJames Jorgensen
Apr 1, 1993·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M SeguraA Sitges-Serra
Jan 25, 2003·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Vicki M Ross

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