Clinical predictors of proteinuric remission following an LN flare - evidence from the UK JSLE cohort study

Pediatric Rheumatology Online Journal
Eve M D SmithUK JSLE Study Group

Abstract

Proteinuria is a well-known risk factor for progression of renal dysfunction in a variety of chronic kidney diseases. In adult-onset Systemic Lupus Erytematosus (SLE) patients with lupus nephritis (LN), proteinuria takes a significant period of time to normalise, with proteinuric remission being associated with improved renal survival and reductions in mortality. The length of time required to attain proteinuric remission has not previously been investigated in Juvenile-onset SLE (JSLE). The aim of this study was to elucidate when proteinuric remission occurs, and whether clinical/demographic factors at LN onset bear influence on the time to proteinuric remission. Participants of the UK JSLE Cohort Study and Repository were included if they had active LN (renal biopsy and/or renal British Isles Lupus Assessment Grade (BILAG) score defined active LN) and proteinuria. Univariate Cox proportional hazard regression modelling was used to explore factors associated with time to proteinuric recovery. Covariates with p-value < 0.2 were included in a multivariable Cox regression model, and backward stepwise variable selection applied. 64/350 (18%) of UK JSLE Cohort Study patients fulfilled the study inclusion criteria. 25 (39%) achieved...Continue Reading

References

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Jul 5, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eve M D Smith, Michael W Beresford

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Citations

Dec 7, 2019·Journal of Inflammation·Rachael D WrightMichael W Beresford
Jul 25, 2021·International Journal of Molecular Sciences·James Greenan-BarrettCoziana Ciurtin
Dec 12, 2018·Journal of Proteome Research·Veronica G AnaniaW Rodney Mathews

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

BILAG
R
MICE

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