Clinical predictors of SARS-CoV-2 neutralizing antibody titers in COVID-19 convalescents: Implications for convalescent plasma donor recruitment.

European Journal of Haematology
Daniele Focosi, Massimo Franchini

Abstract

While COVID-19 convalescent plasma (CCP) efficacy is still under investigation in randomized controlled trials (RCT), CCP collections continue worldwide with largely variable criteria. Since it is well known that only a minority of patients develop high-titer neutralizing antibodies (nAb), as assessed by the viral neutralization tests (VNT), strategies to maximize cost-effectiveness of CCP collection are urgently needed. A growing amount of the population is having exposure to the virus and is hence becoming a candidate CCP donor. Laboratory screening with high-throughput serology has good correlations with the VNT titer, but upstream screening using clinical surrogates would be advisable. We review here the existing literature on clinical predictors of high-titer nAb. Older age, male sex, and hospitalization are the main proxies of high VNT and should drive CCP donor recruitment.

References

Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Jun 13, 2020·Nature Reviews. Immunology·Eileen P ScullySabra L Klein
Jul 8, 2020·The Journal of Clinical Investigation·Yanqun WangJincun Zhao
Aug 9, 2020·The Journal of Clinical Investigation·Sabra L KleinAaron Ar Tobian
Aug 31, 2020·Mayo Clinic Proceedings·Michael J JoynerR Scott Wright
Sep 4, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Roberto Gozalbo-RoviraDavid Navarro
Sep 11, 2020·The Journal of Infectious Diseases·Sarah E BennerAndrew D Redd
Sep 27, 2020·Transfusion·Christof JungbauerThomas R Kreil
Nov 25, 2020·The New England Journal of Medicine·Ventura A SimonovichUNKNOWN PlasmAr Study Group
Dec 29, 2020·The Journal of Infectious Diseases·Jéromine KlinglerCatarina E Hioe
Jan 7, 2021·The New England Journal of Medicine·Romina LibsterUNKNOWN Fundación INFANT–COVID-19 Group
Feb 2, 2021·The New England Journal of Medicine·Michael J JoynerArturo Casadevall
Feb 11, 2021·Nature·Zijun WangMichel C Nussenzweig
Mar 12, 2021·The Journal of Infectious Diseases·Ludivine GrzelakSamira Fafi-Kremer

❮ Previous
Next ❯

Citations

Apr 21, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Daniele FocosiFrancesco Menichetti
Jul 29, 2021·IScience·Paola de CandiaGiuseppe Matarese
Sep 2, 2021·Military Medical Research·Natalie Yan-Lin PangDe-Yun Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.