Clinical predictors of survival in metastatic uveal melanoma

Japanese Journal of Ophthalmology
Daniel LorenzoJosep Maria Caminal

Abstract

To determine the clinical factors that influence survival in patients with metastatic uveal melanoma. Single-center, retrospective review of patients' medical records. The following data of ninety-nine consecutive patients (49 men, 50 women) with metastatic uveal melanoma were registered: patient demographics; primary tumor characteristics; features of first melanoma-related metastasis; symptoms and patient status at distant disease debut and metastasis treatment. Overall survival was analyzed by Kaplan-Meier estimates. A Cox proportional hazards regression model was applied to identify independent predictors associated with survival. Mean patient age at metastatic diagnosis was 60.7 years (standard deviation, 12.8). The liver was the first metastatic site in most (92.9%) cases. The median disease-free interval was 26 months (interquartile range, 34). Median overall survival after detection of the first metastasis was 8 months (interquartile range, 14). The baseline characteristics of the primary uveal melanoma were not associated with survival in patients with stage IV disease. In the multivariate analysis, the following factors at first metastatic diagnosis were associated with improved overall survival: disease-free interval...Continue Reading

References

Dec 1, 1991·AJR. American Journal of Roentgenology·J G LoriganG M Mavligit
Mar 1, 1991·Ophthalmology·E S GragoudasM D Spar
Jan 1, 1988·Survey of Ophthalmology·K M EganD M Albert
Jul 15, 1983·Cancer·S RajpalC P Karakousis
Jan 9, 2003·Cancer·Sebastian EskelinTero Kivelä
Feb 14, 2004·American Journal of Ophthalmology·Igor KaisermanJacob Pe'er
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie Diener-WestUNKNOWN Collaborative Ocular Melanoma Study Group Report 23
May 14, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Laurent KodjikianMichel Rivoire
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Petra RietschelPaul B Chapman
May 15, 2007·Ophthalmology·Gianni VirgiliUNKNOWN EUROCARE Working Group
May 12, 2009·The British Journal of Ophthalmology·S FrenkelJ Pe'er
Aug 12, 2009·Archives of Ophthalmology·Carol L ShieldsJerry A Shields
May 24, 2011·American Journal of Ophthalmology·James J AugsburgerNikolaos Trichopoulos
Jun 28, 2011·Ophthalmology·Arun D SinghAllan K Topham
Apr 21, 2012·Melanoma Research·Josep Maria CaminalJorge Arruga
Jun 12, 2012·Ophthalmology·Frédéric MouriauxAlain Rousseau
Aug 17, 2012·Melanoma Research·Paula L BlancoMiguel N Burnier
Nov 26, 2013·International Journal of Cancer. Journal International Du Cancer·Kenneth D Bishop, Adam J Olszewski
Jan 10, 2014·Cancer Medicine·Kristina BuderMatthias Goebeler
Aug 15, 2014·Nature Reviews. Cancer·María Soledad SosaJulio A Aguirre-Ghiso
Aug 19, 2014·Journal of Cancer Research and Clinical Oncology·Li-Li ChenCheng-Bao Zhu
Apr 2, 2015·Indian Journal of Ophthalmology·Swathi KalikiJerry A Shields
Nov 26, 2015·American Journal of Ophthalmology·Zélia M Corrêa, James J Augsburger
Dec 4, 2015·JAMA Ophthalmology·Maria M ChoudharyArun D Singh
Mar 19, 2016·Cancer·Chandrani ChattopadhyaySapna P Patel

❮ Previous
Next ❯

Citations

Jul 25, 2019·Cancers·Bertil E DamatoRichard D Carvajal
Aug 21, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark R MiddletonMario Sznol
Jan 9, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José María PiulatsAlfonso Berrocal-Jaime
Jan 17, 2021·The British Journal of Ophthalmology·Gaurav GargUNKNOWN AJCC Ophthalmic Oncology Task Force
May 26, 2020·Seminars in Cancer Biology·Prisca BustamanteJulia V Burnier
Feb 13, 2021·European Journal of Ophthalmology·Sven Holger BaumChristopher Mohr
Feb 10, 2021·Cancer Cell International·Qiuqiu ZhangHan Zhang
Mar 18, 2021·BMC Ophthalmology·Rui FangWen-Bin Wei
Jul 3, 2021·Mathematical Biosciences and Engineering : MBE·Li-Sha PanHao Liang
Jun 22, 2021·Frontiers in Oncology·Naoki TakahashiIchiro Yasuda
Sep 23, 2021·The New England Journal of Medicine·Paul NathanUNKNOWN IMCgp100-202 Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.