Clinical Presentation and Gene Expression Profiling of Immunoglobulin M Multiple Myeloma Compared With Other Myeloma Subtypes and Waldenström Macroglobulinemia

Journal of Global Oncology
Shebli AtrashBart Barlogie

Abstract

Multiple myeloma (MM) is a clonal bone marrow disease characterized by the neoplastic transformation of differentiated postgerminal B cells. It is a heterogeneous disease both at the genetic level and in terms of clinical outcome. Immunoglobulin M (IgM) MM is a rare subtype of myeloma. Similar to Waldenström macroglobulinemia (WM), patients with MM experience IgM monoclonal gammopathy; however, both diseases are distinct in terms of treatment and clinical behavior. To shed light on the presentation of IgM MM, its prognosis, and its gene expression profiling, we identified and characterized 21 patients with IgM MM from our database. One of these patients presented with a rare IgM monoclonal gammopathy of undetermined significance that progressed to smoldering myeloma. The median survival of the 21 patients was 4.9 years, which was comparable to a matched group of patients with non-IgM MM with similar myeloma prognostic factors (age, gender, albumin, creatinine, anemia, lactate dehydrogenase, β2-microglobulin, cytogenetics abnormalities), but much less than the median survival reported for patients with WM (9 years). We identified a cluster of genes that differ in their expression profile between MM and WM and found that the pati...Continue Reading

References

Jan 1, 1977·Acta Haematologica·Y Krausz, A Zlotnick
Aug 1, 1985·The Journal of Clinical Investigation·B BarlogieL Smith
Aug 1, 1987·Mayo Clinic Proceedings·R A Kyle, J P Garton
Jul 1, 1995·Cancer Genetics and Cytogenetics·J R SawyerB Barlogie
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A DimopoulosM Dalakas
Oct 19, 2001·Oncogene·P L Bergsagel, W M Kuehl
Mar 29, 2002·The Hematology Journal : the Official Journal of the European Haematology Association·X TroussardB Sola
Jan 17, 2003·Mayo Clinic Proceedings·Robert A KylePhilip R Greipp
Apr 30, 2003·Seminars in Oncology·Hervé Avet-LoiseauRégis Bataille
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip R GreippJan Westin
Dec 12, 2007·Best Practice & Research. Clinical Haematology·Hervé Avet-Loiseau
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Sep 16, 2010·American Journal of Hematology·Steven R SchusterJoseph Mikhael
Apr 2, 2011·Clinical Lymphoma, Myeloma & Leukemia·Saad UsmaniBart Barlogie
Apr 13, 2012·Nature Reviews. Cancer·Gareth J MorganFaith E Davies
Sep 21, 2013·American Journal of Clinical Pathology·Rebecca L KingWilliam G Morice

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Citations

Oct 1, 2019·Cytometry. Part B, Clinical Cytometry·Hao-Wei Wang, Pei Lin
Jul 8, 2020·Cancers·Louis-Pierre GirardSanjay de Mel

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Methods Mentioned

BETA
biopsy
Fluorescence
flow cytometry
PCA
imaging technique

Software Mentioned

Database for Annotation , Visualization , and Integrated Disco...
MIRT
R
SVM
MatchIT

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