Clinical presentation and initial management of black men and white men with prostate cancer in the United Kingdom: the PROCESS cohort study.

British Journal of Cancer
S EvansY Ben-Shlomo

Abstract

In the United States, Black men have a higher risk of prostate cancer and worse survival than do White men, but it is unclear whether this is because of differences in diagnosis and management. We re-examined these differences in the United Kingdom, where health care is free and unlikely to vary by socioeconomic status. This study is a population-based retrospective cohort study of men diagnosed with prostate cancer with data on ethnicity, prognostic factors, and clinical care. A Delphi panel considered the appropriateness of investigations and treatments received. At diagnosis, Black men had similar clinical stage and Gleason scores but higher age-adjusted prostate-specific antigen levels (geometric mean ratio 1.41, 95% confidence interval (95% CI): 1.15-1.73). Black men underwent more investigations and were more likely to undergo radical treatment, although this was largely explained by their younger age. Even after age adjustment, Black men were more likely to undergo a bone scan (odds ratio 1.37, 95% CI: 1.05-1.80). The Delphi analysis did not suggest differential management by ethnicity. This UK-based study comparing Black men with White men found no evidence of differences in disease characteristics at the time of prosta...Continue Reading

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Citations

Aug 1, 2014·International Journal of Biological Sciences·Shahriar KoochekpourKristopher Attwood
Dec 26, 2015·International Journal of Environmental Research and Public Health·Adeodat IlboudoOlorunseun O Ogunwobi
Jan 1, 2016·Nature Reviews. Urology·Kathleen F McGinleyJudd W Moul
Feb 21, 2018·Health Research Policy and Systems·Roberto Grilli, Valentina Chiesa
Jun 18, 2010·BJU International·Daniel A Barocas, David F Penson
Aug 11, 2011·British Journal of Cancer·P Kheirandish, F Chinegwundoh
Apr 12, 2014·The Prostate·Elizabeth A TindallVanessa M Hayes
Oct 11, 2013·Journal of the Royal Army Medical Corps·Ed BarnardE Nicol
Apr 22, 2011·BJU International·Mark Frydenberg
Aug 26, 2020·Expert Opinion on Drug Metabolism & Toxicology·Gabriel TaoRomi Ghose
Aug 16, 2017·Current Urology Reports·Zachary L SmithAdam B Murphy
Nov 23, 2013·The American Journal of Medicine·Tisheeka Graham-SteedJohn Concato
Aug 13, 2010·Current Opinion in Supportive and Palliative Care

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Software Mentioned

Stata
PROCESS

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