Clinical Presentation and Outcomes of Children With Human Granulocytic Anaplasmosis

Journal of the Pediatric Infectious Diseases Society
Anna M SchotthoeferHolly M Frost

Abstract

Adults with the tick-borne disease human granulocytic anaplasmosis (HGA) have a spectrum of acute febrile illnesses that, if untreated, might be severe. Clinical presentation and outcomes of children with HGA have been poorly described. A retrospective analysis was conducted to determine the frequency, presentation, and outcomes of pediatric patients with HGA between 1994 and 2015 in a region of Wisconsin in which HGA is highly endemic. Patients with related International Classification of Diseases Ninth and Tenth Revision (ICD-9 and ICD-10, respectively) codes or positive HGA laboratory test results were evaluated and classified as having had confirmed, probable, or suspected HGA on the basis of the Centers for Disease Control and Prevention (CDC) case definition. The Fisher's exact and Wilcoxon rank-sum tests were used in statistical comparisons. Of 187 children identified with possible HGA, 17 (9%) had confirmed, 75 (40%) had probable, and 91 (49%) had suspected infections. The number of cases rose sharply in 2010 and has remained between 16 and 36 cases per year since that time. A minority of children with confirmed or probable infections had elevated liver transaminase levels (33%), leukopenia (24%), thrombocytopenia (17%)...Continue Reading

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Citations

Jul 19, 2020·International Journal of Environmental Research and Public Health·Austin RauJesse D Berman
Mar 6, 2021·International Journal for Parasitology. Parasites and Wildlife·Tao LiDayong Tao
Jul 22, 2021·Emerging Infectious Diseases·Alexis RussellP Bryon Backenson

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