Abstract
Adults with the tick-borne disease human granulocytic anaplasmosis (HGA) have a spectrum of acute febrile illnesses that, if untreated, might be severe. Clinical presentation and outcomes of children with HGA have been poorly described. A retrospective analysis was conducted to determine the frequency, presentation, and outcomes of pediatric patients with HGA between 1994 and 2015 in a region of Wisconsin in which HGA is highly endemic. Patients with related International Classification of Diseases Ninth and Tenth Revision (ICD-9 and ICD-10, respectively) codes or positive HGA laboratory test results were evaluated and classified as having had confirmed, probable, or suspected HGA on the basis of the Centers for Disease Control and Prevention (CDC) case definition. The Fisher's exact and Wilcoxon rank-sum tests were used in statistical comparisons. Of 187 children identified with possible HGA, 17 (9%) had confirmed, 75 (40%) had probable, and 91 (49%) had suspected infections. The number of cases rose sharply in 2010 and has remained between 16 and 36 cases per year since that time. A minority of children with confirmed or probable infections had elevated liver transaminase levels (33%), leukopenia (24%), thrombocytopenia (17%)...Continue Reading
References
Mar 1, 1994·Journal of Clinical Microbiology·S M ChenD H Walker
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E A BelongiaM E Schriefer
Apr 6, 2000·The Journal of Infectious Diseases·J W IJdoR W Ryder
Dec 26, 2001·The Journal of Infectious Diseases·E A BelongiaJ P Davis
Jun 14, 2003·Vector Borne and Zoonotic Diseases·Maria E Aguero-Rosenfeld
Jul 14, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Stephen DumlerJohan S Bakken
Jul 8, 2011·The American Journal of Tropical Medicine and Hygiene·F Scott DahlgrenJennifer H McQuiston
Aug 5, 2011·The New England Journal of Medicine·Bobbi S PrittMarina E Eremeeva
Mar 6, 2012·Mayo Clinic Proceedings·Ana A WeilMark S Drapkin
May 3, 2013·Journal of Clinical Microbiology·A M SchotthoeferT R Fritsche
Jun 28, 2013·Journal of Medical Entomology·Xia LeeSusan M Paskewitz
Apr 15, 2015·The American Journal of Tropical Medicine and Hygiene·F Scott DahlgrenCasey Barton Behravesh
May 23, 2015·Infectious Disease Clinics of North America·Johan S Bakken, J Stephen Dumler
Jan 20, 2016·Journal of Medical Entomology·Rebecca J EisenCharles B Beard
May 7, 2016·Parasites & Vectors·Mark P NelderDoug Sider
May 14, 2016·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Holly M BiggsMarc S Traeger
Aug 26, 2016·International Journal of Systematic and Evolutionary Microbiology·Bobbi S PrittJeannine M Petersen
Citations
Feb 7, 2019·Frontiers in Physiology·Hui WangJingze Liu
Jul 19, 2020·International Journal of Environmental Research and Public Health·Austin RauJesse D Berman
Mar 6, 2021·International Journal for Parasitology. Parasites and Wildlife·Tao LiDayong Tao
Jul 22, 2021·Emerging Infectious Diseases·Alexis RussellP Bryon Backenson