Clinical presentation and outcomes of COVID-19 in older hospitalised patients assessed by the record-based multidimensional prognostic index, a cross-sectional study.

European Geriatric Medicine
Ane Borgbjerg VerholtLone Winther Lietzen

Abstract

Older people are the most frequently hospital admitted patients with COVID-19. We aimed to describe the clinical presentation of COVID-19 among frail and nonfrail older hospitalised patients and to evaluate the potential association between frailty and clinical course, decision of treatment level with outcomes change in functional capacity and survival. We performed a multi-center, retrospective cross-sectional cohort study examining data on clinical presentation and frailty-related domains for hospitalised people aged 75 + years with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test. Frailty was assessed at admission using record-based MPI (rMPI) and Clinical Frailty Scale (CFS). Decision on treatment level about invasive ventilation and cardiopulmonary resuscitation (CPR), change in CFS-score from admission to discharge, changed need of home care, and in-hospital, 30-day and 90-day mortality were registered. 100 patients (median age 82 years (IQR 78-86), 56% female) with COVID-19 were included. 54 patients were assessed moderately or severely frail (rMPI-score = 2 or 3) and compared to non-frail (rMPI-score = 1). At admission, frail patients presented more frequently with confusion. At discharge, fu...Continue Reading

References

Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
May 12, 2007·Journal of the American Geriatrics Society·Sharon K InouyeGeorge A Kuchel
Aug 13, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ryan Zarychanski, Donald S Houston
Feb 12, 2013·Lancet·Andrew CleggKenneth Rockwood
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
Jan 24, 2017·JAMA Psychiatry·Daniel H J DavisUNKNOWN Epidemiological Clinicopathological Studies in Europe (EClipSE) Collaborative Members
Sep 13, 2017·The Cochrane Database of Systematic Reviews·Graham EllisSasha Shepperd
Oct 24, 2019·The Journal of Nutrition, Health & Aging·E DentB Vellas
Apr 30, 2020·The Journal of Nutrition, Health & Aging·F LandiR Bernabei
May 27, 2020·Intensive Care Medicine·Giuseppe BellelliUNKNOWN COVID-19 Monza Team members
May 30, 2020·European Geriatric Medicine·Merete GregersenElse Marie Damsgaard
Jun 20, 2020·European Geriatric Medicine·Troels K HansenMerete Gregersen
Jul 4, 2020·The Lancet. Public Health·Jonathan HewittUNKNOWN COPE Study Collaborators
Jul 18, 2020·Journal of the American Medical Directors Association·Robert De SmetMichaël R Laurent
Jul 18, 2020·Palliative Medicine·Michele FiorentinoNina E Glass
Jul 24, 2020·The Journal of Hospital Infection·B CarterUNKNOWN COPE Study Collaborators
Aug 2, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shigeru ShibataHiroshi Itoh
Aug 22, 2020·Age and Ageing·Alessandra MarengoniDebora Rizzuto
Aug 25, 2020·Journal of the American Geriatrics Society·Flavia B GarcezThiago J Avelino-Silva
Nov 4, 2020·Journal of the American Medical Directors Association·Aline MendesDina Zekry
Nov 20, 2020·JAMA Network Open·Maura KennedySharon K Inouye
Jan 22, 2021·Archives of Gerontology and Geriatrics·Linda Katharina KarlssonCecilia Margareta Lund
Apr 6, 2021·Journal of the American Geriatrics Society·Márlon Juliano Romero AlibertiUNKNOWN COVID HCFMUSP Study Group
Apr 22, 2021·Archives of Gerontology and Geriatrics·Alberto PilottoUNKNOWN Italian Geriatric Society Hospital and Community (SIGOT) Study Group

❮ Previous
Next ❯

Software Mentioned

REDCap
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.