Clinical presentation and prognostic factors in sodium monofluoroacetate intoxication

Journal of Toxicology. Clinical Toxicology
C H ChiJ J Huang

Abstract

The diagnosis of sodium monofluoroacetate intoxication in humans is usually based on a history of ingestion and clinical findings. Although several previous reports have described the clinical course and outcome of patients who ingested this drug, prognostic indicators of short-term survival are not available. A retrospective study of 38 consecutive cases of sodium monofluoroacetate poisoning at the National Cheng Kung. University Hospital, 1988-1993, to analyze the clinical findings and to predict mortality. Seven of 38 patients (18%) died. The most common symptom was nausea or vomiting (74%). The most frequent ECG finding was nonspecific ST-T and T wave abnormalities (72%). Hypocalcemia (42%) and hypokalemia (65%) were the common electrolyte abnormalities. The clinical and laboratory characteristics were compared for the survival and mortality groups. Significant differences in hypotension, respiratory rate, pulse rate, creatinine, potassium, elevated alanine aminotransferase, pH, PCO2, APACHE II score, and subjective respiratory distress were noted. Discriminant analysis identified hypotension, increased serum creatinine, and decreased pH as the most important predictors of mortality, with sensitivity of 86% and specificity ...Continue Reading

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Citations

Aug 14, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alex F ManiniRobert S Hoffman
May 8, 2007·Emergency Medicine Clinics of North America·Christopher P HolstegeStephen G Dobmeier
Jul 21, 1999·Human & Experimental Toxicology·C H ChiK W Chen
Apr 19, 2018·American Journal of Therapeutics·Claudia Lucía Arroyave HoyosSalomé Lopera Cardona
Aug 31, 2006·Analytical and Bioanalytical Chemistry·Nadezhda L KoryaginaAndrey S Radilov
Oct 28, 2005·Journal of Applied Toxicology : JAT·Nikolay V GoncharovAndrey S Radilov
Feb 10, 2007·Toxicological Reviews·Alex T ProudfootJ Allister Vale

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