Clinical presentation and severity of viral community-acquired pneumonia in young Nepalese children

The Pediatric Infectious Disease Journal
Maria MathisenHalvor Sommerfelt

Abstract

Most deaths from pneumonia in children <5 years of age occur in developing countries, where information about the clinical impact and severity of viral causes of respiratory infections is limited. From June 29, 2004 to June 30, 2007 we evaluated 2230 cases of pneumonia (World Health Organization criteria) in children aged 2 to 35 months in Bhaktapur, Nepal. A nasopharyngeal aspirate from each case was examined for 7 respiratory viruses using reverse-transcription polymerase chain reaction. We compared illness duration, severity, and treatment failure between cases positive and negative for the individual viruses in multiple regression models. A total of 2219 cases had a valid polymerase chain reaction result and were included in the analyses. Overall, 46.1% of cases were 2 to 11 months of age. Being infected with respiratory syncytial virus (RSV) was associated with lower chest indrawing (odds ratio [OR] 2.17; 95% confidence interval [CI] 1.42-3.30) and, among infants, oxygen saturation <93% (OR: 1.88; CI: 1.32-2.69). Among the 2088 nonsevere pneumonia cases, those positive for RSV had a longer time to recovery (hazard ratio 0.82; CI 0.75-0.90; P < 0.001) and an increased risk of treatment failure (OR: 1.75; CI: 1.34-2.28; P < ...Continue Reading

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Citations

Feb 7, 2014·BMC Infectious Diseases·Paul TurnerFrancois Nosten
Jan 7, 2014·PloS One·Jennifer R VeraniKim A Lindblade
Jan 28, 2015·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Hannah V ThorntonAlastair D Hay
Mar 31, 2010·The Pediatric Infectious Disease Journal·Maria MathisenHalvor Sommerfelt
Dec 5, 2018·International Journal of Microbiology·Bishnu Prasad UpadhyayPrakash Ghimire

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