Abstract
Canine non-infectious inflammatory meningoencephalomyelitis is termed meningoencephalomyelitis of unknown origin (MUO) and may affect dogs of every breed at any age. Treatment with immunosuppressive medication, the survival time based on MRI, and cerebrospinal fluid (CSF) findings has been widely reported; however, these studies only included a small number of patients, or they are summaries from the literature. Therefore, the aim of this study was to compare the clinical presentation, diagnostic findings, treatment protocol and long-term survival time in many dogs diagnosed with MUO in one clinic with previously published studies. One hundred eighty-two dogs met the inclusion criteria. Age, sex, duration of clinical signs before diagnosis, presence of neurological signs, MRI and CSF analysis were similar to those in previous reports. Our study revealed that dogs with a brainstem lesion have a 60% lower chance of death before 1 year than dogs with multifocal brain lesions. A total of 55.56% of treated dogs survived for more than 1 year, and 10.55% survived for more than 5 years since diagnosis. The median survival time for all dogs was 540 days. Our findings support glucocorticosteroid monotherapy as a viable treatment option f...Continue Reading
References
Aug 1, 1975·The Journal of Clinical Endocrinology and Metabolism·P L BallardJ D Baxter
Jun 1, 1975·The Journal of Clinical Endocrinology and Metabolism·H L CantrillB Becker
Jul 10, 2007·The Journal of Small Animal Practice·P F AdamoW M Adams
Jan 8, 2008·The Journal of Veterinary Medical Science·Dong-In JungHee-Myung Park
Feb 26, 2008·The Veterinary Record·P MenautC Trumel
Jan 20, 2009·The Veterinary Record·A PakozdyJ G Thalhammer
May 5, 2009·The Veterinary Journal·Nicolas GrangerNick D Jeffery
Aug 4, 2009·Journal of Veterinary Internal Medicine·P M SmithN D Jeffery
Oct 10, 2009·The Journal of Small Animal Practice·Lauren R Talarico, Scott J Schatzberg
Oct 16, 2010·Journal of the American Veterinary Medical Association·Michael A WongJeff D Clarke
Feb 2, 2011·Journal of the American Veterinary Medical Association·Thomas FlegelDiana Henke
Mar 7, 2013·The Veterinary Record·M LowrieL Garosi
Sep 23, 2014·The Veterinary Clinics of North America. Small Animal Practice·Joan R Coates, Nicholas D Jeffery
Feb 1, 2015·Acta Veterinaria Scandinavica·Katrin BeckmannCarla Rohrer Bley
Oct 13, 2015·Journal of Veterinary Emergency and Critical Care·Itai BarnoonOrit Chai
May 12, 2016·The Veterinary Record·I CornelisS De Decker
Jun 1, 2016·The Veterinary Journal·M LowrieL Garosi
Jul 9, 2016·The Veterinary Journal·I CornelisS De Decker
Oct 25, 2016·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Bonnie J OliphantJennifer M White
Jun 29, 2015·Veterinary Medicine and Science·Miyu Mercier, Heidi L Barnes Heller
Mar 9, 2019·Journal of Veterinary Internal Medicine·James W SwannNathaniel T Whitley