Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain

Open Forum Infectious Diseases
Carmen de MendozaHTLV Spanish Study Group

Abstract

Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and ...Continue Reading

References

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Citations

Mar 12, 2019·Journal of Synchrotron Radiation·S AbeghyanJ Pflueger
Jan 19, 2019·Chemistry & Biodiversity·Thalía I Ramírez-ReyesJosé A Guerrero-Analco
Feb 20, 2020·AIDS·José-Manuel RamosUNKNOWN Spanish HTLV Network
Feb 24, 2021·ACS Chemical Biology·Gordon J LockbaumCelia A Schiffer
Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Carolina RosadasRicardo Ishak
May 20, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Carolina RosadasRicardo Ishak

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