PMID: 2240497Oct 1, 1990

Clinical presentation of suspected malignant hyperthermia during anaesthesia in 402 probands

F R EllisA S Christian


As anaesthetists have become more aware of malignant hyperthermia the mortality rate has fallen, but concommitantly the number of dubious and aborted cases has increased. All probands who developed a suspected malignant hyperthermia reaction during anaesthesia and subsequently underwent muscle biopsy were classified according to the clinical presentation. A probability for malignant hyperthermia can be calculated, using the classification, for each type of clinical presentation; this varied from 0.96 to 0.07. Certain clinical features were found to be of more value as predictors than others; these included a high creative kinase and myoglobinuria. The accuracy of prediction depends on a clear contemporaneous description of the clinical events.


Sep 1, 1990·British Journal of Anaesthesia·A UrwylerP M Hopkins
Nov 1, 1988·British Journal of Anaesthesia·S T OhnishiA K Brownell
Feb 1, 1987·Acta Neurologica Scandinavica·C LennmarkenK G Henriksson
Aug 1, 1986·Anaesthesia·F R EllisD G Harriman
Oct 1, 1985·British Journal of Anaesthesia·M Sosis, M Goldberg
Jul 1, 1970·Canadian Anaesthetists' Society Journal·B A Britt, W Kalow
Oct 1, 1984·Muscle & Nerve·G D EngS M Muldoon
Apr 1, 1984·British Journal of Anaesthesia·J E StevensK Mori


Oct 10, 2002·Forensic Science International : Synergy·B Karger, K Teige
May 21, 2009·British Journal of Anaesthesia·R L RobinsonM-A Shaw
Aug 4, 2009·British Journal of Anaesthesia·D CarpenterP M Hopkins
Jun 1, 2011·British Journal of Anaesthesia·P M Hopkins
Nov 1, 1991·Anaesthesia·A A BroekemaP J Hennis
May 13, 1999·Paediatric Anaesthesia·S N KhalilJ F Teichgraeber
Oct 3, 2006·Current Opinion in Anaesthesiology·P J Adnet, G A Gronert
Apr 17, 2008·Anaesthesia·S S O'Neill, G J Smurthwaite
Nov 6, 2009·Fundamental & Clinical Pharmacology·Paula Lima do CarmoR T Sudo
Oct 16, 2010·Anaesthesia·P K Gupta, P M Hopkins
Jun 17, 1998·The American Journal of Medicine·J Loke, D H MacLennan
Jul 19, 2015·British Journal of Anaesthesia·P M HopkinsEuropean Malignant Hyperthermia Group
May 14, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R T SudoG Zapata-Sudo
Aug 6, 2000·British Journal of Anaesthesia·P M Hopkins
Jan 24, 2007·Paediatric Anaesthesia·Monalisa BonciuMarc Raucoules Aimé
Jul 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·P J HalsallP M Hopkins
Apr 8, 2000·Anesthesiology·F Wappler, M Fiege

Related Concepts

Macro-Creatine Kinase
Disease Susceptibility
Malignant Hyperpyrexia due to Anesthesia
Masseter Muscle Structure
Generalized Spasms

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