PMID: 2240497Oct 1, 1990

Clinical presentation of suspected malignant hyperthermia during anaesthesia in 402 probands

Anaesthesia
F R EllisA S Christian

Abstract

As anaesthetists have become more aware of malignant hyperthermia the mortality rate has fallen, but concommitantly the number of dubious and aborted cases has increased. All probands who developed a suspected malignant hyperthermia reaction during anaesthesia and subsequently underwent muscle biopsy were classified according to the clinical presentation. A probability for malignant hyperthermia can be calculated, using the classification, for each type of clinical presentation; this varied from 0.96 to 0.07. Certain clinical features were found to be of more value as predictors than others; these included a high creative kinase and myoglobinuria. The accuracy of prediction depends on a clear contemporaneous description of the clinical events.

References

Sep 1, 1990·British Journal of Anaesthesia·A UrwylerP M Hopkins
Nov 1, 1988·British Journal of Anaesthesia·S T OhnishiA K Brownell
Feb 1, 1987·Acta Neurologica Scandinavica·C LennmarkenK G Henriksson
Aug 1, 1986·Anaesthesia·F R EllisD G Harriman
Oct 1, 1985·British Journal of Anaesthesia·M Sosis, M Goldberg
Jul 1, 1970·Canadian Anaesthetists' Society Journal·B A Britt, W Kalow
Oct 1, 1984·Muscle & Nerve·G D EngS M Muldoon
Apr 1, 1984·British Journal of Anaesthesia·J E StevensK Mori

Citations

Oct 10, 2002·Forensic Science International : Synergy·B Karger, K Teige
May 21, 2009·British Journal of Anaesthesia·R L RobinsonM-A Shaw
Aug 4, 2009·British Journal of Anaesthesia·D CarpenterP M Hopkins
Jun 1, 2011·British Journal of Anaesthesia·P M Hopkins
Nov 1, 1991·Anaesthesia·A A BroekemaP J Hennis
May 13, 1999·Paediatric Anaesthesia·S N KhalilJ F Teichgraeber
Oct 3, 2006·Current Opinion in Anaesthesiology·P J Adnet, G A Gronert
Apr 17, 2008·Anaesthesia·S S O'Neill, G J Smurthwaite
Nov 6, 2009·Fundamental & Clinical Pharmacology·Paula Lima do CarmoR T Sudo
Oct 16, 2010·Anaesthesia·P K Gupta, P M Hopkins
Jun 17, 1998·The American Journal of Medicine·J Loke, D H MacLennan
Jul 19, 2015·British Journal of Anaesthesia·P M HopkinsEuropean Malignant Hyperthermia Group
May 14, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R T SudoG Zapata-Sudo
Aug 6, 2000·British Journal of Anaesthesia·P M Hopkins
Jan 24, 2007·Paediatric Anaesthesia·Monalisa BonciuMarc Raucoules Aimé
Jul 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·P J HalsallP M Hopkins
Apr 8, 2000·Anesthesiology·F Wappler, M Fiege

Related Concepts

Macro-Creatine Kinase
Disease Susceptibility
Malignant Hyperpyrexia due to Anesthesia
Masseter Muscle Structure
Muscle
Myoglobinuria
Probability
Rhabdomyolysis
Generalized Spasms

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