Abstract
Corneal graft rejection is the most common reason for the failure of an allograft corneal transplant. We undertook this study to identify and compare risk factors and treatment outcomes for early and late corneal graft rejections after optical penetrating keratoplasty. A retrospective case file analysis of 880 primary penetrating keratoplasties was performed at a tertiary ophthalmic care centre. Patients were divided into early rejectors (rejection episode within 6 months postoperatively) and late rejectors (rejection episode after 6 months postoperatively). Main parameters evaluated were demographics, preoperative diagnosis and clinical signs, donor tissue details, surgical technique, details of rejection episode, treatment, and outcome information. A total of 156 patients with rejection episodes were identified. Of these, 42 (26.9%) patients experienced early rejection episodes and 114 (73.1%) patients experienced late rejection episodes. Preoperative donor and recipient characteristics, surgical technique, and clinical presentation of graft rejection were found to be similar between both groups after a Bonferroni correction was applied (P>0.005). Treatment outcomes of graft rejections were not significantly different (P=0.46...Continue Reading
References
Mar 1, 1990·Survey of Ophthalmology·S E Wilson, H E Kaufman
Jul 1, 1990·Survey of Ophthalmology·J W Streilein
Jun 15, 1989·American Journal of Ophthalmology·H M BoisjolyJ Bernier
Feb 1, 1987·Australian and New Zealand Journal of Ophthalmology·H J Völker-DiebenC C Kok-van Alphen
Dec 15, 1994·Transplantation·A VailW J Armitage
Sep 1, 1994·Ophthalmology·M G MaguireA Schwartz
Oct 29, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T ReinhardR Sundmacher
Aug 1, 1997·The British Journal of Ophthalmology·A VailW J Armitage
Mar 5, 1998·The British Journal of Ophthalmology·K A WilliamsD J Coster
Nov 27, 1999·The British Journal of Ophthalmology·T HuddeD F Larkin
Sep 6, 2000·Transplantation·H J Völker-DiebenJ D'Amaro
Nov 30, 2000·Clinical & Experimental Ophthalmology·N H BarkerK A Williams
Mar 15, 2001·Cornea·M SitA R Slomovic
Jul 24, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael KüchleGottfried O H Naumann
Mar 30, 2006·Transplantation·Keryn A WilliamsDouglas J Coster
Nov 7, 2007·Transplantation·Keryn A Williams, Douglas J Coster
Apr 5, 2008·Ophthalmology·UNKNOWN Cornea Donor Study Investigator GroupDavid D Verdier
Dec 6, 2008·American Journal of Ophthalmology·Steven P DunnUNKNOWN Cornea Donor Study Investigator Group
Apr 18, 2009·Eye·I RahmanA Tullo
Sep 3, 2009·Cornea·Joel SugarUNKNOWN Group Cornea Donor Study Investigator Group
Citations
Sep 5, 2013·Ophthalmology·Virgilio GalvisMario L Revelo
Oct 8, 2014·World Journal of Surgery·Jian-Feng ChenJia-Hong Dong
Mar 29, 2014·Molecular Medicine Reports·Bing LiXuefeng Wang
Aug 14, 2020·The British Journal of Ophthalmology·Jorge L AlioJorge Luis Alio Del Barrio
Aug 8, 2021·Journal of Clinical Medicine·Orlaith McGrathJane Ashworth