Clinical presentation, risk factors and treatment outcomes of first allograft rejection after penetrating keratoplasty in early and late postoperative period.

Eye
Chandrashan PereraR B Vajpayee

Abstract

Corneal graft rejection is the most common reason for the failure of an allograft corneal transplant. We undertook this study to identify and compare risk factors and treatment outcomes for early and late corneal graft rejections after optical penetrating keratoplasty. A retrospective case file analysis of 880 primary penetrating keratoplasties was performed at a tertiary ophthalmic care centre. Patients were divided into early rejectors (rejection episode within 6 months postoperatively) and late rejectors (rejection episode after 6 months postoperatively). Main parameters evaluated were demographics, preoperative diagnosis and clinical signs, donor tissue details, surgical technique, details of rejection episode, treatment, and outcome information. A total of 156 patients with rejection episodes were identified. Of these, 42 (26.9%) patients experienced early rejection episodes and 114 (73.1%) patients experienced late rejection episodes. Preoperative donor and recipient characteristics, surgical technique, and clinical presentation of graft rejection were found to be similar between both groups after a Bonferroni correction was applied (P>0.005). Treatment outcomes of graft rejections were not significantly different (P=0.46...Continue Reading

References

Mar 1, 1990·Survey of Ophthalmology·S E Wilson, H E Kaufman
Jun 15, 1989·American Journal of Ophthalmology·H M BoisjolyJ Bernier
Feb 1, 1987·Australian and New Zealand Journal of Ophthalmology·H J Völker-DiebenC C Kok-van Alphen
Oct 29, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T ReinhardR Sundmacher
Aug 1, 1997·The British Journal of Ophthalmology·A VailW J Armitage
Nov 27, 1999·The British Journal of Ophthalmology·T HuddeD F Larkin
Sep 6, 2000·Transplantation·H J Völker-DiebenJ D'Amaro
Nov 30, 2000·Clinical & Experimental Ophthalmology·N H BarkerK A Williams
Mar 15, 2001·Cornea·M SitA R Slomovic
Jul 24, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael KüchleGottfried O H Naumann
Nov 7, 2007·Transplantation·Keryn A Williams, Douglas J Coster
Apr 5, 2008·Ophthalmology·UNKNOWN Cornea Donor Study Investigator GroupDavid D Verdier
Dec 6, 2008·American Journal of Ophthalmology·Steven P DunnUNKNOWN Cornea Donor Study Investigator Group
Sep 3, 2009·Cornea·Joel SugarUNKNOWN Group Cornea Donor Study Investigator Group

❮ Previous
Next ❯

Citations

Sep 5, 2013·Ophthalmology·Virgilio GalvisMario L Revelo
Oct 8, 2014·World Journal of Surgery·Jian-Feng ChenJia-Hong Dong
Aug 14, 2020·The British Journal of Ophthalmology·Jorge L AlioJorge Luis Alio Del Barrio
Aug 8, 2021·Journal of Clinical Medicine·Orlaith McGrathJane Ashworth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Ophthalmology
Chandrashan PereraR B Vajpayee
Ophthalmology
Alan SugarCornea Donor Study Investigator Group
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Abdul Al-Muammar, William G Hodge
© 2022 Meta ULC. All rights reserved