Clinical presentations, risk factors, treatment and outcomes in patients with splanchnic vein thrombosis: a single-center experience

Journal of Thrombosis and Thrombolysis
Kelsey KluteMaria T DeSancho

Abstract

Splanchnic vein thrombosis (SVT) is an uncommon form of venous thrombosis. Management can be challenging due to underlying conditions, increased bleeding risk, and lack of evidence from clinical trials. We sought to characterize the presentation and management of patients with SVT at a large tertiary hospital. A total of 43 patients' electronic medical records were reviewed. Median age at diagnosis was 43 (18-71). Sixteen patients had isolated portal vein thrombosis (37.2 %), and 16 (37.2 %) had thrombosis involving multiple splanchnic veins. Abdominal pain was the most common clinical presentation (67.4 %). Thrombophilia was present in 18 patients (41.9 %), nine had underlying liver disease (20.9 %) and seven had inflammatory bowel disease (16.3 %). Thirty-nine (90.7 %) patients were treated with anticoagulation, and 11(25.6 %) of these patients underwent interventional procedures. Thirty (69.8 %) patients remained on indefinite anticoagulation. Results of follow-up imaging at least 1 month after diagnosis were available for 29 patients; imaging showed chronic, stable thrombosis in 14 patients (48.3 %), resolution of thrombosis in 13 patients (44.8 %) and asymptomatic progression in two patients (6.9 %). Recurrent thrombosis o...Continue Reading

References

Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Aug 12, 2009·Journal of Hepatology·Jildou HoekstraUNKNOWN European Network for Vascular Disorders of the Liver
Aug 14, 2012·British Journal of Haematology·Campbell TaitUNKNOWN British Committee for Standards in Haematology
Oct 3, 2012·Thrombosis Research·Nicoletta RivaWalter Ageno
Nov 2, 2012·European Journal of Gastroenterology & Hepatology·Lucio AmitranoFilippo Lampasi
Jul 17, 2013·British Journal of Haematology·Mallika SekharAndrew K Burroughs
Nov 21, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Deepti MutrejaRenu Saxena
Jan 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Melissa MartinezRaj Vuppalanchi
Jul 19, 2014·Digestive Diseases·Marcello BianchiniErica Villa
Oct 15, 2014·Zeitschrift für Gastroenterologie·K LenzM Voglmayr
Jun 23, 2015·The New England Journal of Medicine·Charles V PollackJeffrey I Weitz
Nov 13, 2015·The New England Journal of Medicine·Deborah M SiegalMark A Crowther

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Citations

Mar 16, 2017·Clinical and Molecular Hepatology·Filippo LeonardiErica Villa
Oct 8, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Malene Helligsø KirkebyAnne-Mette Hvas

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