PMID: 11920453Mar 29, 2002Paper

Clinical pretreatment risk factors and Ga-67 scintigraphy early during treatment for prediction of outcome of patients with aggressive non-Hodgkin lymphoma

Cancer
O IsraelD Front

Abstract

Clinical pretreatment risk factors indicate the severity of disease in patients with aggressive non-Hodgkin lymphoma (NHL). Ga-67 scintigraphy during treatment is an early indicator of treatment-related features of lymphoma cells. The ability of risk factors and Ga-67 to predict disease outcome was compared in 139 patients with aggressive NHL. Pretreatment clinical risk factors and Ga-67 scintigraphy performed after one cycle and at mid-treatment were evaluated for their correlation with response rate and as predictors of 5-year failure-free survival (FFS). Univariate analysis was performed to determine the ability of pretreatment risk factors and Ga-67 early during treatment to predict FFS. Subsequently, multivariate analysis was performed on the variables with significant univariate results using the Cox proportional hazards method. The predictive value of risk factors and Ga-67 scintigraphy was calculated to determine their suitability in selecting patients with poor outcome. Response rate correlated with stage of disease (P < 0.01) and the international prognostic index (IPI) score (P < 0.05). Five-year FFS was predicted by stage of disease (P < 0.004), performance status (P < 0.02), and the IPI score (P < 0.01). Response r...Continue Reading

References

May 1, 1990·Radiology·D FrontE Robinson
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Aug 6, 2000·Seminars in Nuclear Medicine·R Bar-ShalomM D Blaufox

❮ Previous
Next ❯

Citations

Oct 4, 2002·Hematological Oncology
Jul 2, 2003·Journal of the American College of Surgeons·Leonidas G KoniarisRabih Salloum
Apr 6, 2004·Nuclear Medicine Communications·S KinuyaN Tonami
May 7, 2008·Nuclear Medicine Communications·Nasser S BallaniFarha H Al-Enezi
Dec 20, 2005·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Alain RahmouniEmmanuel Itti
Mar 18, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lale KostakogluStanley J Goldsmith
Sep 13, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Paolo TomaAlberto Garaventa
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Jul 31, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Kang ShanLi Yan
Jul 28, 2006·Annals of Hematology·Solène QuerellouOlivier Couturier
Mar 20, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Einat Even-Sapir, Ora Israel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.