Abstract
To analyze the clinical profile and outcomes of patients with nonvalvular atrial fibrillation treated with rivaroxaban in a regional hospital. Retrospective study of patients with nonvalvular atrial fibrillation that started treatment with rivaroxaban between July 2013 and May 2017 in a regional hospital. 189 patients (age 76.0 ± 9.4 years; CHA2DS2-VASc 4.1 ± 1.7; HAS-BLED 2.1 ± 0.9) were included. Rivaroxaban 20 mg was taken by 74.1% of patients. Among patients treated with rivaroxaban 20 and 15 mg, only 3.6 and 22.5%, respectively, received an inadequate dose. After 26.6 ± 11.6 months of treatment, annual discontinuation rate was 1%. Rates of stroke, major bleeding and intracranial hemorrhage were 0.45, 0.22 and 0.22 events/100 patient years, respectively. In our practice of regional hospital, rates of discontinuation, thromboembolic and bleeding outcomes are low.
References
Feb 25, 2009·European Journal of Internal Medicine·Philippe AmouyelHervé Lamarque
Sep 19, 2009·Chest·Gregory Y H LipHarry J G M Crijns
Mar 20, 2010·Chest·Ron PistersGregory Y H Lip
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Feb 15, 2013·Expert Review of Cardiovascular Therapy·Vivencio Barrios, Carlos Escobar
Dec 10, 2013·Lancet·Christian T RuffElliott M Antman
May 27, 2014·Blood·Jan Beyer-WestendorfNorbert Weiss
Jan 7, 2015·Journal of the Saudi Heart Association·Ralph J Verdino
Feb 20, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan Beyer-WestendorfNorbert Weiss
May 4, 2015·European Journal of Internal Medicine·Rolf P EngelbergerNils Kucher
Sep 4, 2015·European Heart Journal·A John CammUNKNOWN XANTUS Investigators
Jan 23, 2016·Thrombosis and Haemostasis·Judith HeckerJan Beyer-Westendorf
Jul 22, 2016·JAMA Cardiology·Jonathan C HsuGregory M Marcus
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Oct 30, 2016·PloS One·Sylvia HaasUNKNOWN GARFIELD-AF Investigators
Jan 17, 2017·Atencion primaria·Leonardo Gregorio Antúnez SánchezCarmen Suárez Serrano
Mar 21, 2017·Expert Review of Cardiovascular Therapy·Gonzalo Barón-EsquiviasMarcelo Sanmartín Fernandez
Mar 24, 2017·International Journal of General Medicine·Maegan M WhitworthEric J MacLaughlin
Mar 30, 2017·Journal of Comparative Effectiveness Research·Ma Del Mar Contreras MuruagaUNKNOWN ALADIN Study Investigators
Jun 10, 2017·Journal of the American College of Cardiology·Xiaoxi YaoPeter A Noseworthy
Aug 6, 2017·Mayo Clinic Proceedings·Michał MazurekGregory Y H Lip
Aug 31, 2017·Journal of Managed Care & Specialty Pharmacy·Colleen A McHorneyEric D Peterson
Oct 19, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammEric Peterson