Clinical profile and outcomes of acute cardiorenal syndrome type-5 in sepsis: An eight-year cohort study

PloS One
Saraschandra VallabhajosyulaJacob C Jentzer

Abstract

To evaluate the clinical features and outcomes of acute cardiorenal syndrome type-5 in patients with severe sepsis and septic shock. Historical cohort study of all adult patients with severe sepsis and septic shock admitted to the intensive care units (ICU) at Mayo Clinic Rochester from January 1, 2007 through December 31, 2014. Patients with prior renal or cardiac dysfunction were excluded. Patients were divided into groups with and without cardiorenal syndrome type-5. Acute Kidney Injury (AKI) was defined by both serum creatinine and urine output criteria of the AKI Network and the cardiac injury was determined by troponin-T levels. Outcomes included in-hospital mortality, ICU and hospital length of stay, and one-year survival. Of 602 patients meeting the study inclusion criteria, 430 (71.4%) met criteria for acute cardiorenal syndrome type-5. Patients with cardiorenal syndrome type-5 had higher severity of illness, greater vasopressor and mechanical ventilation use. Cardiorenal syndrome type-5 was associated higher unadjusted in-hospital mortality, ICU and hospital lengths of stay, and lower one-year survival. When adjusted for age, gender, severity of illness and mechanical ventilation, cardiorenal syndrome type-5 was indep...Continue Reading

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Citations

Jul 5, 2019·ESC Heart Failure·Saraschandra VallabhajosyulaKianoush Kashani
Nov 24, 2018·Annals of Intensive Care·Saraschandra VallabhajosyulaVivek N Iyer
Jul 25, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Saraschandra VallabhajosyulaGregory W Barsness
Mar 20, 2018·Journal of Intensive Care Medicine·Saraschandra VallabhajosyulaJacob C Jentzer
Oct 30, 2018·Journal of the American Heart Association·Saraschandra VallabhajosyulaAnkit Sakhuja
Sep 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saraschandra VallabhajosyulaVirginia M Miller
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Aug 27, 2021·Journal of Cardiovascular Development and Disease·Sohrab SinghSaraschandra Vallabhajosyula

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