Clinical Profile and Response to Treatment with Pegylated Interferon α 2b and Ribavirin in Chronic Hepatitis C-A Reappraisal from a Tertiary Care Center in Northern India

Journal of Clinical and Experimental Hepatology
Vinod K DixitAshok K Jain

Abstract

To assess the clinical profile of 80 chronic hepatitis C patients in a tertiary health care center in Northern India and also to study the efficacy and tolerability of pegylated interferon (Peg-IFN) α 2b and ribavirin therapy in a cohort of chronic hepatitis C patients. Thirty subjects with chronic hepatitis C (CH-C) with genotypes 2 and 3 received Peg-IFN α 2b 1.5 μg/kg subcutaneously weekly plus daily ribavirin 800 mg for 24 weeks .Subjects with genotype 1 infection received therapy for 48 weeks with ribavirin 1000 mg/day and Peg-IFN α 2b dose remained the same. The primary end point was the sustained viral response (SVR). Drug dosage was modified or temporarily discontinued if anemia or bone marrow suppression developed. The clinical profile of chronic hepatitis C infected patients showed decompensated cirrhosis in the more elderly patients. Genotype 3 was the commonest genotype and was seen in 21 (70%) patients. The mean baseline HCV RNA was high. SVR was achieved less commonly with genotype 1 than with genotype 2/3. Patients who became negative for HCV RNA at 4-weeks (rapid virological response or RVR) and 12 weeks (early virological response or EVR) of treatment showed significantly higher sustained virological response (...Continue Reading

References

Jun 15, 1990·Annals of Internal Medicine·J M Sánchez-TapiasM P Gil
Feb 1, 1996·Journal of Medical Virology·A K PanigrahiS K Panda
Aug 29, 1998·Journal of Hepatology·M Martinot-PeignouxP Marcellin
Feb 19, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sukanya RaghuramanPriya Abraham
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Abhijit ChowdhuryDebendra Nath Guha Mazumder
Jan 24, 2004·Journal of Hepatology·Vincent Agnello, Francesco G De Rosa
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doris B StraderUNKNOWN American Association for the Study of Liver Diseases
Aug 12, 2004·Journal of Gastroenterology and Hepatology·Sidhartha HazariSubrat Kumar Acharya
Sep 4, 2004·Seminars in Liver Disease·Peter Ferenci
Dec 8, 2006·The New England Journal of Medicine·Jay H Hoofnagle, Leonard B Seeff
Jan 2, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·K Rajender ReddyMichael Fried
Apr 21, 2007·Journal of Gastroenterology and Hepatology·UNKNOWN Asian Pacific Association for the Study of the Liver (APASL) Hepatitis C Working PartyR Tateishi
Feb 12, 2009·Journal of Biosciences·Ashis Mukhopadhyaya
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shobha NarahariDhananjaya Saranath
Nov 3, 2009·The New England Journal of Medicine·Marc A PfefferUNKNOWN TREAT Investigators
Aug 18, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ira M JacobsonChristian Trépo
Aug 27, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Irene RayBinay K De
Jun 23, 2011·BMC Infectious Diseases·Nanna HansenUNKNOWN Danish Database for Hepatitis B and C (DANHEP)- group
Apr 23, 2013·Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation·Ajay DusejaVinay Sakhuja
Apr 1, 2012·Clinical Liver Disease·Douglas L Nguyen, Timothy R Morgan

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Citations

Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Swastik Agrawal, Radha K Dhiman

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