Clinical profile of primary hyperparathyroidism in adolescents and young adults

Clinical Endocrinology
K C LohOrlo H Clark

Abstract

Primary hyperparathyroidism (PHPT) is an uncommonly diagnosed condition among adolescents and young adults. We review the clinical characteristics of these patients based on our institutional experience. Patients aged 12-28 years treated for PHPT at our institution from 1990 to 1996 were evaluated by a review of medical records and current follow-up data. This consisted of 22 patients (8M:14F), constituting approximately 3% of all patients operated for PHPT during this period. Serum and urinary calcium concentrations, renal function, and serum intact parathyroid hormone (IPTH) levels were measured in all patients. After biochemical confirmation of diagnosis, the patients completed a questionnaire to evaluate the presence of symptoms and/or conditions associated with PHPT. All the patients underwent parathyroidectomy and their tumour characteristics were evaluated. Surgical outcome was determined by measurements of serum calcium and IPTH levels postoperatively and during long-term follow-up. A third of the patients were diagnosed by routine serum chemistry whereas two-thirds presented with symptoms or conditions associated with hypercalcaemia. Non-specific complaints such as fatigue or exhaustion, and weakness or lethargy consti...Continue Reading

References

Jun 1, 1976·The Journal of Urology·R S Malek, P P Kelalis
May 11, 1975·American Journal of Surgery·H Mannix
Apr 11, 1991·Nature·T MotokuraA Arnold
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S J SilverbergM V Parisien
Nov 1, 1989·Journal of Pediatric Surgery·W M StoneD Zimmerman
May 1, 1986·Journal of Pediatric Surgery·D RapaportM Dintsman
Sep 23, 1985·Ugeskrift for laeger·K Lillquist, J H Kristiansen
Mar 1, 1973·Cancer·A Schantz, B Castleman
May 1, 1970·Acta paediatrica Scandinavica·A BjernulfI Werner
Nov 1, 1982·World Journal of Surgery·M AlloR H Nishiyama
Jan 24, 1980·The New England Journal of Medicine·H HeathM A Kennedy
May 1, 1995·Genes, Chromosomes & Cancer·V L CrynsA Arnold
Jun 1, 1995·The Surgical Clinics of North America·B K MitchellB K Kinder
Mar 17, 1994·The New England Journal of Medicine·V L CrynsA Arnold
Sep 1, 1996·The Journal of Clinical Endocrinology and Metabolism·C DotzenrathC Larsson
Dec 1, 1996·QJM : Monthly Journal of the Association of Physicians·M L LawsonS W Kooh
Apr 18, 1997·Science·S C ChandrasekharappaS J Marx

❮ Previous
Next ❯

Citations

Nov 28, 2012·Pediatric Surgery International·Itai PashtanEdwin L Kaplan
Jun 18, 2009·Langenbeck's Archives of Surgery·Denis WirowskiPeter E Goretzki
Dec 6, 2008·Journal of Bone and Mineral Metabolism·Ediz YeşilkayaSedat Demircan
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Benzion JoshuaThomas Shpitzer
Jan 25, 2003·Clinical Nuclear Medicine·Thomas Leitha, Anton Staudenherz
May 20, 2011·The Journal of Clinical Endocrinology and Metabolism·Amanda D BenaderetAmbika P Ashraf
Dec 12, 2012·Case Reports in Endocrinology·B DhamijaG A Solanki
Dec 6, 2014·Journal of Pediatric Surgery·S AlagaratnamT R Kurzawinski
Sep 20, 2012·Journal of the Chinese Medical Association : JCMA·Jeffrey Roizen, Michael A Levine
Feb 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Bart L Clarke
Jul 14, 2010·Journal of Pediatric Surgery·Emily T DurkinRebecca S Sippel
Jan 13, 2009·The Journal of Surgical Research·Mark S SneiderJohn I Lew
Jun 3, 2008·International Journal of Pediatric Otorhinolaryngology·Petr LibánskýJirí Sedý
Jul 10, 2016·American Journal of Surgery·Irene LouDawn M Elfenbein
May 21, 2017·Endocrine·Federica SaponaroFilomena Cetani
Oct 19, 2004·World Journal of Surgery·Kenko CupistiKlaus-Martin Schulte
Oct 6, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Soham MukherjeeArunanshu Behera
May 3, 2007·The Laryngoscope·Frederic VenailMichel Mondain
Jan 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·Sjur ReppeKaare M Gautvik
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Mark J BollandIan R Reid
Dec 8, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·James NormanDouglas Politz
Dec 10, 2016·Endocrinology, Diabetes & Metabolism Case Reports·Anna CasteràsJordi Mesa
May 4, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Samim OzenSukran Darcan
May 20, 2000·Clinical Orthopaedics and Related Research·M S KocherA R Perez-Atayde
Jan 19, 2021·Medical Hypotheses·Kelly McKennaKourosh Parham
Mar 2, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Matthew Philip DaviesSaba P Balasubramanian
May 4, 2021·Case Reports in Endocrinology·Gerdi TuliLuisa De Sanctis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Benzion JoshuaThomas Shpitzer
QJM : Monthly Journal of the Association of Physicians
M L LawsonS W Kooh
Journal of Pediatric Endocrinology & Metabolism : JPEM
D DamianiN Setian
© 2022 Meta ULC. All rights reserved