Clinical Profiles and Conversion Rates Among Young Individuals With Autism Spectrum Disorder Who Present to Clinical High Risk for Psychosis Services

Journal of the American Academy of Child and Adolescent Psychiatry
Jennifer H Foss-FeigCarrie E Bearden

Abstract

The overlap versus independence of autism spectrum disorder (ASD) and schizophrenia is a topic that has garnered the attention of generations of clinicians and scientists. Although high rates of psychotic symptoms have been identified in individuals with ASD, the nature, prevalence, and prognostic significance of subclinical psychotic experiences in ASD remain poorly understood. This study sought to compare baseline characteristics, clinical profiles, and conversion outcomes between young individuals at clinical high risk for psychosis (CHR) who presented with or without a prior ASD diagnosis during the second phase of the North American Prodrome Longitudinal Study (NAPLS, N = 764). Patients with CHR and ASD (CHR/ASD+, n = 26) tended to exhibit greater social and social cognitive difficulties, but expressed relatively levels of core psychosis symptoms similar to those of to patients with CHR but no ASD (CHR/ASD-). Risk for conversion to co-occurring psychosis (18.2% CHR/ASD+ versus 16.8% CHR/ASD-) was equivalent between CHR/ASD+ and CHR/ASD- groups, and the NAPLS2 Psychosis Risk Calculator predicted conversion to psychosis equally well across groups. These results suggest that baseline psychosis symptoms, predictors of risk for...Continue Reading

Citations

Mar 2, 2021·European Child & Adolescent Psychiatry·Amandeep JutlaJennifer H Foss-Feig
Apr 10, 2021·Frontiers in Neuroscience·Jessica MaiuoloVincenzo Mollace
Aug 8, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Ulla LångIan Kelleher
Dec 31, 2021·Autism Research : Official Journal of the International Society for Autism Research·Amandeep JutlaJeremy Veenstra-VanderWeele

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