Clinical proteomics and breast cancer

The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Bashar A ZeidanRamsey I Cutress

Abstract

Breast cancer is a heterogeneous disease. Yet, many molecular players and mechanisms behind the complexity of its clinical behaviour remain unknown, and advances in biomedical research are expected to unravel novel molecular discoveries in breast and other cancers. Clinical proteomics is currently experiencing rapid advances in technology that promise new means to improve breast cancer early diagnosis, stratification, and treatment response. We reviewed recent literature adopting clinical proteomics in breast cancer research. This review highlights the principles, advantages, limitations, discoveries and future prospects of recent clinical proteomics discovery efforts in breast cancer research. Numerous proteomic studies of breast cancer have been accomplished aiming to aid the development of personalised therapies, increase understanding of post treatment relapse, and help improve prediction of patient prognosis. This has led to the possible identification of profiles refining breast cancer subtypes and the discovery of novel biomarkers pointing towards diagnostic and prognostic potential.

References

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Citations

Dec 15, 2015·Expert Review of Proteomics·Radwa EwaishaKaren S Anderson
Nov 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Haiping SongTao Huang
Aug 9, 2016·Journal of Proteomics·Stephany CorrêaEliana Abdelhay
May 11, 2017·Proteomics. Clinical Applications·Sadr-Ul ShaheedChris W Sutton
Oct 16, 2015·Breast Cancer : Basic and Clinical Research·Mohamed I NounouHussaini Syed-Sha-Qhattal
Jun 4, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Haiping SongTao Huang
May 19, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·A I AutenschlyusV V Lyakhovich
Aug 2, 2019·Journal of Proteome Research·Yuan-Wan SunKaram El-Bayoumy

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