Clinical, radiographic, and pathologic abnormalities in dogs with multiple epiphyseal dysplasia: 19 cases (1991-2005)

Journal of the American Veterinary Medical Association
A Magnus RørvikFrode Lingaas

Abstract

To determine clinical, radiographic, and pathologic abnormalities in dogs with multiple epiphyseal dysplasia (MED). Retrospective case series. 19 dogs with MED from 10 litters. The diagnosis was made on the basis of radiographs of the shoulder region and vertebral column. Ten dogs underwent necropsy. There were 11 Hygenhund, 6 Dunker, 1 Golden Retriever, and 1 English Pointer. Most dogs were examined because of lameness that developed at 5 to 8 months of age. The most common radiographic abnormality was a deficiency in ossification of the epiphyses, apophyses, and cuboidal bones of the appendicular skeleton and the epiphyses of the vertebrae; ossification of the metaphyses and the diaphyses typically were normal. Disease severity was consistent among littermates, but varied among dogs from different litters. Results suggested that MED is a rare condition in dogs characterized by a deficiency in ossification of the epiphyses of the long bones, the epiphyses of the vertebrae, the cuboidal bones, and the apophyses. Radiographic abnormalities were evident in dogs examined as young as 8 weeks of age, and most dogs had developed severe lameness by 5 to 8 months of age. The condition most likely had an autosomal recessive mode of inhe...Continue Reading

Citations

Jul 26, 2012·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·S Kalff, T Gemmill
Oct 26, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Antonio De SimoneMario Ricciardi
Jun 15, 2021·Journal of the American Veterinary Medical Association·Federico Longo, Alessandro Zotti

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