Clinical, Radiological, and Microbiological Characteristics of Mycobacterium simiae Infection in 97 Patients

Antimicrobial Agents and Chemotherapy
Nathalie Coolen-AllouNicolas Veziris

Abstract

Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of M. simiae in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least 1 sample positive for M. simiae In our cohort, 97 patients (15.1%) were positive for M. simiae Twenty-one patients (21.6%) met the American Thoracic Society (ATS) criteria for infection. M. simiae infection was associated with bronchiectasis, micronodular lesions, and weight loss. Antibiotic susceptibility testing was performed for 60 patients, and the isolates were found to have low susceptibility to antibiotics, except for amikacin, fluoroquinolones, and clarithromycin. Treatment failed for 4 of the 8 patients treated for M. simiae infection. Here, we describe a specific cluster corresponding to a large cohort of patients with M. simiae, a rare nontuberculous mycobacterium associated with low pathogenicity and poor susceptibility to antibiotics.

References

Nov 1, 1965·Archives of Oral Biology·M Kindlová
Jan 1, 1983·The American Review of Respiratory Disease·R C BellW G Johanson
Dec 1, 1982·Tubercle·A Lavy, Y Yoshpe-Purer
Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·G ValeroJ R Graybill
Apr 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D L RynkiewiczN M Ampel
Oct 12, 2000·The Journal of Infection·H M Al-AbdelyJ R Graybill
Jan 26, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beatriz Braun-SaroManuel L Fernández-Guerrero
May 16, 2002·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·J L SampaioJ P Leite
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hana M El SahlyEdward A Graviss
Dec 2, 2006·The European Respiratory Journal·M DaillouxUNKNOWN French Mycobacteria Study Group
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Apr 7, 2007·The Pediatric Infectious Disease Journal·Niraj C PatelFlor M Munoz
Jan 2, 2008·The European Respiratory Journal·J van IngenD van Soolingen
Nov 22, 2011·International Journal of Antimicrobial Agents·Jakko van IngenCharles L Daley
Jul 30, 2014·American Journal of Respiratory and Critical Care Medicine·Jennifer AdjemianD Rebecca Prevots
Jul 30, 2014·Annals of the American Thoracic Society·D Rebecca PrevotsKenneth N Olivier
Jan 28, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Ayeh BaghizadehPoopak Farnia
Jan 31, 2017·Pediatric Pulmonology·Jennifer M BousoOkan Elidemir
Feb 22, 2017·Emerging Infectious Diseases·Jennifer AdjemianD Rebecca Prevots

❮ Previous
Next ❯

Citations

Oct 26, 2018·Antimicrobial Agents and Chemotherapy·Amal HamiehSouha Kanj
May 1, 2020·PLoS Pathogens·Jean-Francois JabbourSouha S Kanj
Jan 25, 2021·Annals of Clinical Microbiology and Antimicrobials·Mehdi Fatahi-Bafghi
Feb 9, 2021·Respirology Case Reports·Hadi LotfiHadi Farsiani
Nov 27, 2020·Curēus·Thomas S FitzMauriceMartin Walshaw
Jan 12, 2021·The Pediatric Infectious Disease Journal·Didier HoNathalie Coolen-Allou
Feb 26, 2021·Respirology Case Reports·Hadi LotfiEhsan Aryan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
M Isolina Campos-HerreroJosé Cuyás
Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Hiroki MoritaMakoto Itoh
The European Respiratory Journal
M DaillouxFrench Mycobacteria Study Group
© 2022 Meta ULC. All rights reserved