Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank.

PloS One
David A KolinO. Elemento

Abstract

Coronavirus disease 2019 (Covid-19) has rapidly infected millions of people worldwide. Recent studies suggest that racial minorities and patients with comorbidities are at higher risk of Covid-19. In this study, we analyzed the effects of clinical, regional, and genetic factors on Covid-19 positive status. The UK Biobank is a longitudinal cohort study that recruited participants from 2006 to 2010 from throughout the United Kingdom. Covid-19 test results were provided to UK Biobank starting on March 16, 2020. The main outcome measure in this study was Covid-19 positive status, determined by the presence of any positive test for a single individual. Clinical risk factors were derived from UK Biobank at baseline, and regional risk factors were imputed using census features local to each participant's home zone. We used robust adjusted Poisson regression with clustering by testing laboratory to estimate relative risk. Blood types were derived using genetic variants rs8176719 and rs8176746, and genomewide tests of association were conducted using logistic-Firth hybrid regression. This prospective cohort study included 397,064 UK Biobank participants, of whom 968 tested positive for Covid-19. The unadjusted relative risk of Covid-19 ...Continue Reading

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Citations

Mar 7, 2021·International Journal of Environmental Research and Public Health·Yael Bar-ZeevYehuda Neumark
Mar 31, 2021·Scandinavian Journal of Immunology·Juan Bautista De SanctisMarián Hajduch
Jun 10, 2021·Genes and Immunity·Sarah C Van AlstenCharles S Rabkin
Jun 25, 2021·HLA : Immune Response Genetics·Renato De MarcoMaria Gerbase-DeLima
Jul 30, 2021·Journal of the American Heart Association·Jordan LoaderJohan Sundström
Sep 4, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Juan Francisco Gutiérrez-BautistaMiguel Ángel López-Nevot
Sep 22, 2021·Signal Transduction and Targeted Therapy·Hao DengLamei Yuan
Nov 14, 2021·Transfusion·Marta Gutiérrez-ValenciaJose Antonio García-Erce

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Methods Mentioned

BETA
genotyping

Software Mentioned

R Foundation for Statistical
PLINK
R

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