Clinical relevance and functional significance of cell-free microRNA-1260b expression profiles in infiltrative myxofibrosarcoma.

Scientific Reports
Takuya MoritaToshifumi Ozaki

Abstract

Infiltrative tumor growth into adjacent soft tissues is a major cause of the frequent recurrence and tumor-related death of myxofibrosarcoma (MFS), but no useful biomarkers reflecting tumor burden and infiltrative growth are available. While emerging evidence suggests a diagnostic and functional role of extracellular/circulating microRNA (miRNA) in various malignant diseases, their significance in MFS patients remains unknown. Global miRNA profiling identified four upregulated miRNAs in MFS patient sera and culture media of MFS cells. Among these, serum miR-1260b level was significantly upregulated in patient serum discriminating from healthy individuals and closely correlated with clinical status and tumor dynamics in MFS-bearing mice. In addition, high miR-1260b expression in serum was correlated with radiological tail-like patterns, characteristic of the infiltrative MFS. The extracellular miR-1260b was embedded in tumor-derived extracellular vesicles (EVs) and promoted cellular invasion of MFS through the downregulation of PCDH9 in the adjacent normal fibroblasts. Collectively, circulating miR-1260b expression may represent a novel diagnostic target for tumor monitoring of this highly aggressive sarcoma. Moreover, EV-miR-12...Continue Reading

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Citations

Oct 14, 2020·EMBO Molecular Medicine·Thomas Gp GrünewaldDominique Heymann

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Methods Mentioned

BETA
surgical resection
biopsy
transmission electron microscopy
dynamic light scattering
transfection
Fluorescence
immunoprecipitation
xenograft
Feature Extraction
Protein Assay

Software Mentioned

Agilent Feature Extraction
GraphPad Prism
Agilent GeneSpring GX
GraphPad

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