Clinical relevance of amphiregulin and VEGF in primary breast cancers

International Journal of Cancer. Journal International Du Cancer
Sylvie DesruisseauY Berthois

Abstract

The characterization of novel prognostic markers in breast cancer is necessary to improve the identification of high-risk populations. In our study, the prognostic significance of VEGF and amphiregulin (AR) was investigated and compared to conventional prognostic factors in primary breast cancers. The analysis was performed using enzyme-linked immuno-assay in a series of 193 patients, and univariate and multivariate analysis were performed in the overall population as well as in pre- and post-menopausal patients subdivided in node-negative (N-) and node-positive (N+) subsets. AR (median, 44.8 pg/mg protein) appeared strongly correlated with progesterone receptors (PgR) (p = 0.0018) in the premenopausal N+ population, and with uPA (p= 0.020) and VEGF (p= 0.0053) in the postmenopausal/N+ patients. Despite these attractive data, AR expression was not significant for recurrence or survival outcome. Data revealed strong correlation between VEGF and uPA, and PAI-1, in the N+ population. Moreover, patients with high VEGF levels displayed poor outcome, with an increased risk for N+ subset. These data were confirmed by multivariate analysis that presented histologic grade (HR, 10.55, p = 0.001) and VEGF (HR, 3.89, p = 0.03) as the promi...Continue Reading

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Citations

May 13, 2008·Journal of Mammary Gland Biology and Neoplasia·Mark D Sternlicht, Susan W Sunnarborg
Apr 25, 2013·Cytokine & Growth Factor Reviews·Shek Man ChimJiake Xu
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Mar 4, 2014·TheScientificWorldJournal·Nancy Bueno FigueiredoCélia Regina Nogueira
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrew A HorwitzJeffrey D Parvin
Sep 4, 2010·Seminars in Cell & Developmental Biology·John FoleyDavid J Riese
Oct 26, 2007·International Journal of Cancer. Journal International Du Cancer·Mana MirzaGeorg F Weber
Oct 4, 2007·British Journal of Cancer·C KutA S Popel
Oct 26, 2018·British Journal of Cancer·Kinga WalaszekGeorg F Weber

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