PMID: 25731628Mar 4, 2015Paper

Clinical relevance of apolipoprotein E genotyping based on a family history of Alzheimer's disease

Current Alzheimer Research
Hilmar K LuckhoffMaritha J Kotze

Abstract

Having a family history of Alzheimer' s disease (AD) may potentiate cumulative risk associated with phenotypic expression of the ε-4 allele of the apolipoprotein E (APOE) gene. In this study, we compared the genotype distribution and allele frequencies of APOE ε-2 (rs7412) and ε -4 (rs429358) in 537 South African individuals participating in a chronic disease screening program, in order to establish whether AD family history modulates the expression of their dyslipidemic effects. Significant differences in the genotype distribution for APOE ε-2 (p=0.034) as well as APOE ε-4 (p=0.038) were found between study participants with (n=67) and without (n=470) a family history of AD. LDL cholesterol levels were inversely associated with physical activity in the study group with a positive family history of AD (p<0.001) but not in those with a negative family history of AD (p=0.257). Similar to its existing use in the diagnosis of monogenic dyslipidemias such as familial hypercholesterolemia, clinical inquiry regarding family history was identified as an important determinant of eligibility for APOE genotyping performed in the context of chronic disease risk management. To our knowledge, this is the first study to demonstrate the modula...Continue Reading

Citations

Jan 27, 2017·Neural Regeneration Research·Xue-Bin LiJun-Li Wang
Aug 21, 2018·The Journal of Nervous and Mental Disease·Huikun NiuBo Li
Oct 8, 2015·Journal of Alzheimer's Disease : JAD·Seok Woo MoonArthur W Toga

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