Clinical relevance of cortical network dynamics in early primary progressive MS.

Multiple Sclerosis : Clinical and Laboratory Research
C TurOlga Ciccarelli

Abstract

Structural cortical networks (SCNs) reflect the covariance between the cortical thickness of different brain regions, which may share common functions and a common developmental evolution. SCNs appear abnormal in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases, but have never been assessed in primary progressive multiple sclerosis (PPMS). The aim of this study was to test whether SCNs are abnormal in early PPMS and change over 5 years, and correlate with disability worsening. A total of 29 PPMS patients and 13 healthy controls underwent clinical and brain magnetic resonance imaging (MRI) assessments for 5 years. Baseline and 5-year follow-up cortical thickness values were obtained and used to build correlation matrices, considered as weighted graphs to obtain network metrics. Bootstrap-based statistics assessed SCN differences between patients and controls and between patients with fast and slow progression. At baseline, patients showed features of lower connectivity (p = 0.02) and efficiency (p < 0.001) than controls. Over 5 years, patients, especially those with fastest clinical progression, showed significant changes suggesting an increase in network connectivity (p < 0.001) and efficiency (p < 0.02...Continue Reading

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Citations

Feb 7, 2020·Human Brain Mapping·Angela RadetzSergiu Groppa
Apr 8, 2020·Annals of Clinical and Translational Neurology·Gabriel Gonzalez-EscamillaSergiu Groppa
Jul 15, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Milagros Hidalgo de la CruzMaria A Rocca
Jan 14, 2021·Nature Reviews. Neurology·Declan T ChardUNKNOWN MAGNIMS Study Group
Apr 22, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Elisa ColatoArman Eshaghi
May 23, 2021·Neurology. Neuroimmunology and Neuroinflammation·Maria A RoccaMassimo Filippi
Jun 15, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Milagros Hidalgo de la CruzMassimo Filippi

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Software Mentioned

FreeSurfer
Stata
MATLAB
Brain Connectivity Toolbox
JIM

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