Clinical relevance of different WHO grade 3 pancreatic neuroendocrine neoplasms based on morphology

Endocrine Connections
Xu HanWenhui Lou

Abstract

Emerging evidence suggests G3 pancreatic neuroendocrine neoplasms (pNENs) present heterogeneous morphology and biology. The 2017 WHO classification has introduced a new category of well-differentiated pancreatic neuroendocrine tumors (WD-pNETs) G3, compared with poorly differentiated pancreatic neuroendocrine carcinomas (PD-pNECs) G3. We aim to analysis the demographics and outcomes of patients with resectable 2017 WHO G3 pNENs to facilitate the distinction between two entities. The multi-institutional retrospective cohort involving 57 surgically treated patients affected by 2017 WHO G3 pNENs were morphologically identified and clinically analyzed. Patients having WD-pNETs G3 and those having PD-pNECs G3 were compared. Thirty patients had WD-pNETs and 27 patients had PD-pNECs. The distributions of Ki-67 and mitotic count in patients with PD-pNECs or WD-pNETs showed remarkable disparities. ROC indicated cut-off value of Ki-67 was 45. PD-pNECs were more common in patients with elevated Ki-67 and mitotic count, advanced AJCC TNM stage, vascular invasion, regional lymph-node metastases, elevated NSE and decreased CgA levels compared with WD-pNETs (P < 0.05). The association between 2017 WHO G3 grade and TTR was statistically signif...Continue Reading

Citations

Mar 30, 2018·Abdominal Radiology·Nam Ju LeeElliot K Fishman
Aug 25, 2018·Gastroenterology Research and Practice·Ilenia BartoliniAntonio Taddei
Aug 21, 2019·Current Treatment Options in Oncology·Mohamad Bassam Sonbol, Thorvardur R Halfdanarson
Jul 29, 2020·Annals of Surgical Oncology·Masayuki TanakaThilo Hackert
Aug 7, 2019·Global Pediatric Health·Zainab Azam Farooqui, Aman Chauhan
Jul 17, 2021·Cancer Letters·Min WangUNKNOWN Minimally Invasive Pancreas Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
dissection

Software Mentioned

SPSS

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