PMID: 11340569May 8, 2001Paper

Clinical relevance of microvessel density in laryngeal squamous cell carcinomas

International Journal of Cancer. Journal International Du Cancer
L PignataroG Pruneri

Abstract

The clinical implications of microvessel density (MVD) in head and neck tumors have not been fully elucidated. We investigated the clinicopathologic correlates and prognostic relevance of MVD in a series of 122 consecutive patients with surgically treated laryngeal squamous cell carcinoma followed-up for a mean of 79 months. MVD was evaluated after CD34 immunostaining in 3 250x microscopic fields representative of the "hot spot" area, and expressed as the mean value of the vessel counts per millimeter squared. The overall median value of the intratumoral vessel count was 69.5/mm(2). In the 20 cases we analyzed, MVD increased significantly from normal to dysplastic mucosa and infiltrating carcinoma (p = 0.0001). Nineteen carcinomas (15.6%) had MVD values that were equal to or lower than the highest MVD value (52.7/mm(2)) observed in normal mucosa samples (in which the median MVD count was 34.5/mm(2), range 16.6-52.7/mm(2), mean 35.1 +/- 11.5/mm(2)) and were therefore considered poorly vascularized. Periodic acid-Schiff (PAS) staining revealed intratumoral PAS-positive connective tissue septa in 13 cases (10.7%). The patients with poorly vascularized tumors showed a tendency toward a better prognosis, but the anatomical site, tum...Continue Reading

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Citations

Nov 12, 2005·Cancer Chemotherapy and Pharmacology·Lei TaoMin Yao
Apr 13, 2010·Angiogenesis·Jacobus F A JansenAmita Shukla-Dave
Oct 7, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rekha V KumarKeerti V Shah
Apr 15, 2006·Journal of Surgical Oncology·Antonello A RomaniPaolo Soliani
May 30, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ruth A JonathanJohannes H A M Kaanders
Jan 20, 2015·Journal of Cellular and Molecular Medicine·Lili QiaoYuan Tian
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Oct 1, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jill A van der ZeeTimo L M ten Hagen
Sep 3, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Zhifei CaoQuansheng Zhou
Mar 7, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Anna RzepakowskaEwa Osuch-Wójcikiewicz
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hedda HaugenClaes Mercke

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