Clinical Relevance of NGAL/MMP-9 Pathway in Patients with Endometrial Cancer

Disease Markers
Aneta Cymbaluk-PłoskaJanusz Menkiszak

Abstract

The objectives of the study were to assess the relationship between the serum levels of MMP-9 and NGAL and the clinical staging and histopathological grade of the tumor. Lipocalin-2/NGAL and MMP-9 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA). The AUC values for NGAL and MMP-9 were 0.9 and 0.78, respectively. The diagnostic potential of NGAL and MMP-9 in differentiating high-stage (FIGO III and IV) and low-stage (FIGO I and II) cancer and predicting the cell differentiation grade (G1 versus G3) on the basis of the analyses of AUC values was determined to be 0.91 and 0.79 for NGAL and 0.82 and 0.84 for MMP-9, respectively. Multifactorial logistic regression analysis in the final method revealed that NGAL and MMP-9 variables were independent of the endometrial cancer risk. OR values for NGAL and MMP-9 were 1.23 (95% CI 1.421-3.27; p = 0.034) and 1.09 (95% CI: 1.38-4.12; p = 0.026), respectively. The NGAL/MMP-9 complex may be useful in the assessment of tumor stage before surgical treatment.

References

Feb 23, 2008·Molecular Endocrinology·Jinhui ZhangXiaoli Chen
Jul 3, 2009·Cell Cycle·Jiang Yang, Marsha A Moses
Feb 1, 2011·International Journal of Biological Sciences·Hsiu-Hsia LinSin-Tak Chu
May 9, 2012·BMC Cancer·Monica MannelqvistLars A Akslen
May 12, 2012·Experimental Diabetes Research·Sheng-Neng XueLi Yan
Dec 12, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ryan J DelahantyXiao-Ou Shu
Jul 26, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Deqiang DingYu-Sheng Cong
Mar 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tianbo LiuGe Lou
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Lalita YadavGeetpriya Kaur
Aug 19, 2015·Molecular and Cellular Endocrinology·Madelaine Cho-ClarkT John Wu
Jan 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Saverio CandidoJerry Polesel
Feb 26, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B CabiaA B Crujeiras
Mar 15, 2016·Molecular and Cellular Endocrinology·Prasad G KambleJan W Eriksson
Apr 28, 2016·Postȩpy higieny i medycyny doświadczalnej·Zofia MarchewkaAgnieszka Piwowar
Dec 3, 2016·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Andrew G Renehan, Isabelle Soerjomataram

❮ Previous
Next ❯

Citations

Jun 11, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Arzu Bostanci DurmusGamze Sinem Caglar
Feb 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuai ShaoGang Wang
Apr 28, 2018·International Journal of Molecular Sciences·Anna SobuśBogusław Machaliński
Feb 12, 2020·International Journal of Molecular Sciences·Bartłomiej BaumertBogusław Machaliński
Jul 10, 2019·Stem Cells International·Wioletta PawlukowskaBogusław Machaliński
Dec 9, 2020·Nutrients·Kaja Michalczyk, Aneta Cymbaluk-Płoska

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
ELISA

Software Mentioned

STASTICA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.