Clinical relevance of occult metastatic cells in the bone marrow of patients with different stages of breast cancer

Clinical Breast Cancer
W JanniS Braun

Abstract

Data are emerging about the prognostic relevance of occult metastatic cells in the bone marrow of patients with various solid tumors. Discrepancies among different studies on the prognostic relevance of isolated tumor cells may be caused by tumor cell heterogeneity and the use of different immunoassays. There is increasing evidence that validated anticytokeratin antibodies (e.g., A45-B/B3) represent the present standard for the detection of isolated tumor cells. This immunocytochemical assay allows the identification of patients with occult tumor cell dissemination that cannot be identified by conventional screening methods in tumor staging. According to recent studies, these patients are at higher risk for subsequent development of distant metastases and might therefore benefit from early systemic therapy. At advanced stages of the disease, the micrometastatic tumor load after adjuvant therapy, or at the time of emerging recurrences, appears to reflect the tumor's ability to progress. Therapeutic monitoring and cell-cycle independent antibody-based therapy are among possible implications of this new, promising diagnostic tool. The present review also focuses on state of the art, reliable detection methods of occult metastatic ...Continue Reading

References

Jun 1, 1977·Cancer·F M Schabel
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·K J HalversonB Fineberg
Jun 1, 1992·Seminars in Cell Biology·J BehrensW Birchmeier
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·C DoglioniG Viale
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J L MansiR C Coombes
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B SalvadoriM I Colnaghi
Jan 1, 1990·Annual Review of Cell Biology·M A SchwarzW W Franke
Apr 1, 1986·American Journal of Surgery·D C BonnheimA Mittelman
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G SchlimokG Riethmüller
Jul 28, 1989·Biochimica Et Biophysica Acta·I R HartR E Wilson
Feb 23, 1989·The New England Journal of Medicine·V T De Vita
Jun 11, 1988·British Medical Journal·M T TraversR C Coombes
Jul 15, 1981·International Journal of Cancer. Journal International Du Cancer·J Taylor-PapadimitriouW F Bodmer
Sep 1, 1993·Journal of the National Cancer Institute·K PantelG Riethmüller
Jan 1, 1994·Journal of Hematotherapy·K PantelG Schlimok
Sep 1, 1994·Journal of Cellular Biochemistry·O Fodstad, I Kjønniksen
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·H J GrossD Recktenwald
Apr 1, 1994·The Journal of Cell Biology·S V LitvinovS O Warnaar
Oct 28, 1993·The New England Journal of Medicine·C C Harris, M Hollstein
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A GoldhirschR D Gelber
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SchlimokG Riethmüller
Feb 23, 1996·Science·R K Jain
Mar 15, 1996·International Journal of Cancer. Journal International Du Cancer·I FunkeK W Jauch
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·K PantelM W Köllermann
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J BlackD M Parkin
Mar 5, 1998·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·T StigbrandJ Hilgers
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·E RacilaJ W Uhr

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Citations

Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janice P Dutcher
Oct 10, 2007·British Journal of Cancer·A Pinzon-CharryJ A López
Sep 15, 2017·Oncotarget·Huiqin Guo, Kangla Tsung

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