Abstract
We investigated immunohistochemically the clinical relevance of the over-expression of the apoptosis-regulating proteins p53 and bcl-2 in a homogeneous series of 149 laryngeal squamous-cell carcinomas. p53 was over-expressed in 75 cases and bcl-2 in 39 cases. p53 and bcl-2 co-expression was found in 21 cases. p53 and bcl-2 immunoreactivity was significantly associated with poor histological differentiation and lymph-node metastases. Moreover, a significant statistical correlation was found between bcl-2 expression, supraglottic tumor site and advanced disease stage. p53/bcl-2 co-expression was significantly associated with poor differentiation, tumor extension, the presence of lymph-node metastases and advanced clinical stage. Univariate analysis showed that a lower probability of survival was significantly associated with supraglottic site, tumor extension, advanced clinical stage and p53/bcl-2 co-expression, but not with p53 or bcl-2 considered separately. In multivariate analysis, only tumor extension and supraglottic site retained their prognostic value. Our data suggest that clinical staging remains the most reliable predictive indicator of survival in patients with laryngeal carcinoma.
References
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·R DolcettiM Boiocchi
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M R Stratton
Jun 28, 1991·Cell·G T Williams
Jul 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J B Morris, D G Cavanagh
Jun 1, 1995·British Journal of Cancer·G D WilsonD A Ross
Feb 1, 1995·Clinical Otolaryngology and Allied Sciences·M A SalamA Morris
Jan 1, 1994·Statistical Methods in Medical Research·J Kay
Feb 1, 1994·British Journal of Cancer·M A PirisF ] Pezella F [corrected to Pezzella
Sep 24, 1993·Cell·S W LoweD E Housman
Nov 1, 1995·The Journal of Pathology·S P Dowell, P A Hall
Apr 17, 1996·Journal of the National Cancer Institute·D M ShinW N Hittelman
Jun 1, 1996·Archives of Otolaryngology--head & Neck Surgery·M F SpaffordW A Franklin
Apr 1, 1996·Histopathology·H J HarnW H Lee
Aug 22, 1996·International Journal of Cancer. Journal International Du Cancer·M SarbiaH E Gabbert
Jun 1, 1996·Histopathology·G PruneriR Buffa
Oct 1, 1996·The Journal of Urology·J J BauerJ W Moul
Jan 27, 1997·International Journal of Cancer. Journal International Du Cancer·N KyprianouJ G Rhee
Jun 19, 1997·Oncogene·A TakaokaK Imai
Jun 20, 1997·International Journal of Cancer. Journal International Du Cancer·U ManneW E Grizzle
Sep 19, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P HirvikoskiV M Kosma
Citations
Nov 24, 1999·Journal of Clinical Pathology·P HirvikoskiV M Kosma
Nov 11, 2009·Annales de pathologie·Cécile BadoualHélène Roussel
Dec 15, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tobias AchTobias Ettl
Sep 25, 2004·Head & Neck·Genevieve A AndrewsJennifer Rubin Grandis
Jan 24, 2008·Head & Neck·Robert P TakesAlfio Ferlito
Dec 29, 2007·Journal of Surgical Oncology·Maria-Kyriaki A KasetaPanayiotis N Soucacos
Oct 10, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·E J GarciaC Cohen
Apr 17, 2001·Head & Neck·H QuonB J Cummings
Apr 5, 2000·Head & Neck·P CapaccioL Pignataro
Aug 15, 2000·The Laryngoscope·M C JäckelL Füzesi
Nov 24, 1999·International Journal of Cancer. Journal International Du Cancer·O GalloB Porfirio
Feb 1, 2007·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·I P GomatosE Ferekidou
Jul 21, 2005·Journal of the National Cancer Institute·Panayiotis A KyzasJohn P A Ioannidis
Dec 13, 2006·International Journal of Oral and Maxillofacial Surgery·T TsujiH Hiratsuka
Mar 27, 2003·The Annals of Otology, Rhinology, and Laryngology·Anastasia GeorgiouEleutherios Ferekidis
Jan 16, 2003·The Journal of International Medical Research·S YildirimZ Pekkafali
Apr 5, 2002·Cancer·Nobuyuki BandohYasuaki Harabuchi
Feb 9, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marcela K Hassumi-FukasawaEdson G Soares
Nov 1, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Lyon L Gleich, Frank N Salamone
Nov 23, 2016·Indian Journal of Surgical Oncology·Arvind SathyamurthyRitika Harjani
Jan 16, 2015·The International Journal of Biological Markers·Federico Maria GioacchiniMassimo Re
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elaine M SmithThomas H Haugen
Aug 25, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A GeorgiouG Androulakis
Sep 24, 1999·Human Pathology·L L LoroA C Johannessen
Jul 10, 2021·Annals of Diagnostic Pathology·Matteo CavaliereClaudia Cassandro