Clinical relevance of parasternal uptake in sentinel node procedure for breast cancer

Journal of Surgical Oncology
Hans F J FabryJoost R M Van der Sijp

Abstract

Preoperative lymphoscintigraphy contributes highly to the accuracy of the sentinel node procedure. Besides routing towards the axilla, in a number of patients additional parasternal focal accumulation may be observed. So far the clinical consequences of this parasternal uptake remains unclarified, i.e., whether any internal mammary lymph node uptake should be surgically biopsied. An analysis of all sentinel node procedures with parasternal uptake was performed. Sixty-nine patients with scintigraphic parasternal uptake and with a minimal follow-up of 24 months, were selected from a prospective database. Tumor characteristics, treatment strategies, and recurrences of these patients were analyzed and subsequently matched against the present day indications for adjuvant treatment. During follow-up (median 41 months) only four (6%) patients developed systemic disease. Initially, three of these patients did not receive adjuvant chemotherapy. Two are alive without evidence of disease after treatment of these recurrences. Currently these patients would, initially, all have been eligible for chemotherapy based on tumor characteristics and age according to international guidelines. For the indication of adjuvant treatment, the status of ...Continue Reading

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Citations

Dec 20, 2005·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Conor D Collins
Oct 15, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Conor D Collins
Jun 2, 2009·Annals of Surgical Oncology·Virginia H StellRichard L White
Feb 18, 2006·Annals of Surgical Oncology·Marjut Hannele Kristiina LeideniusKarl Albert Johan von Smitten
Mar 15, 2005·Seminars in Nuclear Medicine·John N Aarsvold, Naomi P Alazraki
Oct 19, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J HongA J Spillane
Sep 17, 2005·American Journal of Surgery·Anees B ChagparKelly M McMasters
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronald C ChenJennifer R Bellon

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